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PMS2 Antibody - Primary antibody, specific to PMS2, Rabbit IgG

COA COA
    Application:
  • IHC
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab122454
Grouped product items
SKU Size
Availability
 Price Qty
Ab122454-10μl
10μl
2
$66.90
Ab122454-50μl
50μl
1
$189.90
Ab122454-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab122454-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

pAb; Rabbit anti Human PMS2 Antibody; WB, IHC; Unconjugated

View related series
Click to view target information: PMS2 Click to view target information: SMARCA4
Accession#:P54278 (1) Gene ID:5395 (1) PMS2 (1)

Basic Description

Product Name PMS2 Antibody - Primary antibody, specific to PMS2, Rabbit IgG
Synonyms DNA mismatch repair gene homologueantibody | DNA mismatch repair protein PMS2 antibody | H_DJ0042M02.9 antibody | HNPCC4 antibody | Mismatch repair endonuclease PMS2 antibody | Mismatch repair gene PMSL2 antibody | MLH4 antibody | PMS 2 antibody | PMS1 ho
Specifications & Purity ExactAb™, Validated, 0.5 mg/mL
Host species Rabbit
Specificity PMS2
Immunogen A synthetic peptide derived from human PMS2 (AA 9-24)
Positive Control WB: Jurkat, HeLa and SK-N-SH cell lysates. IHC: Human tonsil tissue.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Rabbit anti Human PMS2 Antibody, Polyclonal, could be used for WB, IHC and so on.
Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
Protein Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 0.5 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PMS2 Tbio Mismatch repair endonuclease PMS2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SMARCA4 Tchem Transcription activator BRG1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SMARCA4 Tchem Transcription activator BRG1 (263 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

PMS2 Antibody (Ab122454) - Western Blot
All lanes: PMS2 Antibody (Ab122454) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 96 kDa
Observed band size: 48, 54, 107 kDa
Exposure time: 16.5 s

PMS2 Antibody (Ab122454) - IHC
Immunohistochemistry analysis of paraffin-embedded Human tonsil using PMS2 Antibody (Ab122454). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Application

Application Dilution info
WB

1/500-1/1000
IHC

1/50 - 1/100

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0404020 Certificate of Analysis Apr 01, 2024 Ab122454
ZJ24F0404019 Certificate of Analysis Apr 01, 2024 Ab122454

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