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Recombinant JNK1/JNK2/JNK3 Antibody - Primary antibody, specific to JNK1/JNK2/JNK3, Rabbit IgG

COA COA
    Application:
  • IF/ICC
  • IP
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab111513
Grouped product items
SKU Size
Availability
 Price Qty
Ab111513-10μl
10μl
1
$69.90
Ab111513-50μl
50μl
1
$209.90
Ab111513-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
Ab111513-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,099.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human JNK1/JNK2/JNK3 Antibody; WB, ICC, IF, IP; Unconjugated

View related series
Click to view target information: MAPK8 Click to view target information: MAP3K10 Click to view target information: MAPK9
Accession#:P45983 (2) Accession#:P45984 (2) Accession#:P53779 (2) Gene ID:5599 (3) Gene ID:5601 (2) Gene ID:5602 (2) JNK1 (3) JNK2 (2) JNK3 (2) MAPK10 (2) MAPK8 (3) MAPK9 (2)

Basic Description

Product Name Recombinant JNK1/JNK2/JNK3 Antibody - Primary antibody, specific to JNK1/JNK2/JNK3, Rabbit IgG
Synonyms C Jun kinase 2 antibody | c Jun N terminal kinase 1 antibody | c Jun N terminal kinase 2 antibody | c Jun N terminal kinase 3 antibody | c-Jun N-terminal kinase 1 antibody | JNK 46 antibody | JNK 55 antibody | JNK antibody | JNK-46 antibody | JNK1 antibod
Specifications & Purity Recombinant, ExactAb™, Validated, See COA
Host species Rabbit
Specificity JNK1/JNK2/JNK3
Immunogen A synthetic peptide derived from human JNK1/JNK2/JNK3 (AA 1-400).
Positive Control WB: MCF7, Jurkat and K562 cell lysates. IF/ICC: HeLa cells. IP: HeLa lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human JNK1/JNK2/JNK3 Antibody, Recombinant, could be used for WB, ICC, IF, IP and so on.
Application:
WB: 1/1000-1/2000
ICC/IF: 1/50-1/200
IP: 1/50
Protein Function：
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAPK8 Tchem Mitogen-activated protein kinase 8 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MAPK9 Tchem Mitogen-activated protein kinase 9 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MAPK9 Tchem c-Jun N-terminal kinase 2 (4655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (401 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase, JNK (688 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) - Western Blot
All lanes: Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution
Predicted band size: 46, 54 kDa
Observed band size: 39, 46 kDa
Exposure time: 100.0 s

Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) - IP
Immunoprecipitate (IP) analysis using Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) at 1/50 dilution. (WB with Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) at 1/3000 dilution).

Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) - IF/ICC
Immunofluorescent analysis of HeLa cells, using Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) at 1/50 dilution.

Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513) - IF/ICC
Immunofluorescent analysis of HeLa cells, using Recombinant JNK1/JNK2/JNK3 Antibody (Ab111513).

Application

Application Dilution info
IF/ICC

1/50-1/200

WB

1/1000 - 1/2000
IP

1/50

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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