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Recombinant JNK1 Antibody - Primary antibody, specific to MAPK8, Rabbit IgG

COA COA
    Application:
  • IF/ICC
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab111518
Grouped product items
SKU Size
Availability
 Price Qty
Ab111518-10μl
10μl
2
$66.90
Ab111518-50μl
50μl
1
$199.90
Ab111518-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab111518-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human JNK1 Antibody; WB; Unconjugated

View related series
Click to view target information: MAPK8
Accession#:P45983 (2) Gene ID:5599 (3) JNK1 (3) MAPK8 (3)

Basic Description

Product Name Recombinant JNK1 Antibody - Primary antibody, specific to MAPK8, Rabbit IgG
Synonyms AI849689 antibody | c Jun N terminal kinase 1 antibody | C-JUN kinase 1 antibody | c-Jun N-terminal kinase 1 antibody | EC 2.7.11.24 antibody | JNK 1 antibody | JNK antibody | JNK-46 antibody | JNK1A2 antibody | JNK21B1/2 antibody | MAP kinase 8 antibody
Specifications & Purity ExactAb™, Validated, Recombinant, 1.0 mg/mL
Host species Rabbit
Specificity MAPK8
Immunogen A synthetic peptide derived from human JNK1 (AA 325-343)
Positive Control WB: C6, U937, HeLa, MCF7 and Jurkat cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human JNK1 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 - 1/1000
ICC/IF: 1/50-1/200
Protein Function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Post-translational
Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Antigen affinity purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAPK8 Tchem Mitogen-activated protein kinase 8 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase, JNK (688 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant JNK1 Antibody (Ab111518) - Western Blot
All lanes: Recombinant JNK1 Antibody (Ab111518) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 48 kDa
Observed band size: 42 kDa
Exposure time: 60.0 s


Application

Application Dilution info
WB

1/500-1/1000
IF/ICC

1/50-1/200

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0102421 Certificate of Analysis Jan 15, 2024 Ab111518
ZJ24F0102422 Certificate of Analysis Jan 15, 2024 Ab111518

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