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Recombinant Lck Antibody - Primary antibody, specific to LCK, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab112898
Grouped product items
SKU Size
Availability
 Price Qty
Ab112898-10μl
10μl
2
$66.90
Ab112898-50μl
50μl
1
$189.90
Ab112898-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab112898-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Lck Antibody; WB; Unconjugated

View related series
Click to view target information: LCK
Accession#:P06239 (2) Gene ID:3932 (2) LCK (2)

Basic Description

Product Name Recombinant Lck Antibody - Primary antibody, specific to LCK, Rabbit IgG
Synonyms IMD22 antibody | LCK antibody | Lck p56 antibody | LCK proto-oncogene, Src family tyrosine kinase antibody | LCK_HUMAN antibody | Leukocyte C-terminal Src kinase antibody | LSK antibody | Lymphocyte cell specific protein tyrosine kinase antibody | Lymphoc
Specifications & Purity ExactAb™, Validated, Recombinant, 0.5 mg/mL
Host species Rabbit
Specificity LCK
Immunogen A synthetic peptide derived from human Lck (AA 21-75).
Positive Control WB: Jurkat, Ramos, MOLT-4 and Raji cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Lck Antibody, Recombinant, could be used for WB and so on.

Application:

WB: 1/500-1/1000

Protein Function：
Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 0.5 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

LCK Tclin Tyrosine-protein kinase Lck (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LCK Tclin VHL/Tyrosine-protein kinase Lck (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Lck Antibody (Ab112898) - Western Blot
All lanes: Recombinant Lck Antibody (Ab112898) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 51 kDa
Observed band size: 54 kDa
Exposure time: 52.9 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0202954 Certificate of Analysis Mar 01, 2024 Ab112898
ZJ24F0202953 Certificate of Analysis Mar 01, 2024 Ab112898

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