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Recombinant Kininogen 1 Antibody - Primary antibody, specific to KNG1, Rabbit IgG

    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab112159
Grouped product items
SKU Size
Availability
Price Qty
Ab112159-10μl
10μl
1
$79.90
Ab112159-50μl
50μl
1
$219.90
Ab112159-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$319.90
Ab112159-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90

Recombinant; Rabbit anti Human Kininogen 1 Antibody; WB; Unconjugated

Basic Description

Product Name Recombinant Kininogen 1 Antibody - Primary antibody, specific to KNG1, Rabbit IgG
Synonyms Alpha-2-thiol proteinase inhibitor antibody | BDK antibody | BK antibody | Bradykinin antibody | Bradykinin included antibody | Fitzgerald factor antibody | FLAUJEAC FACTOR antibody | High molecular weight kininogen antibody | HMWK antibody | Ile-Ser-Brad
Specifications & Purity Recombinant, ExactAb™, Validated, High Performance, See COA
Host species Rabbit
Specificity KNG1
Immunogen A synthetic peptide derived from human Kininogen 1 (AA 600-644).
Positive Control WB: Human serum lysates.
Conjugation Unconjugated
Grade ExactAb™, High Performance, Recombinant, Validated
Product Description

Rabbit anti Human Kininogen 1 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/1000-1/5000
Protein Function
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. 
Post-translational
Bradykinin is released from kininogen by plasma kallikrein. Hydroxylation of Pro-383 occurs prior to the release of bradykinin. Phosphorylation sites are present in the extracelllular medium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

KNG1 Tbio Kininogen-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant Kininogen 1 Antibody (Ab112159) - Western Blot
All lanes: Recombinant Kininogen 1 Antibody (Ab112159) at 1/1000 dilution
Samples: Lysates at 20 µL per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 72 kDa
Observed band size: 43, 73, 80 kDa
Exposure time: 7.7 s

Application

Application Dilution info
WB

1/1000 - 1/5000

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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