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Recombinant Glucocorticoid Receptor Antibody - Primary antibody, specific to NR3C1, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Hamster,Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab105558
Grouped product items
SKU Size
Availability
 Price Qty
Ab105558-10μl
10μl
2
$79.90
Ab105558-50μl
50μl
1
$239.90
Ab105558-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$349.90
Ab105558-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Glucocorticoid Receptor Antibody; WB; Unconjugated

View related series
Click to view target information: NR3C1
Accession#:P04150 (1) Gene ID:2908 (1) Glucocorticoid Receptor (103) NR3C1 (1)

Basic Description

Product Name Recombinant Glucocorticoid Receptor Antibody - Primary antibody, specific to NR3C1, Rabbit IgG
Synonyms GCCR antibody | GCR antibody | GCR_HUMAN antibody | GCRST antibody | glucocorticoid nuclear receptor variant 1 antibody | Glucocorticoid receptor antibody | GR antibody | GRL antibody | Grl1 antibody | nr3c1 antibody | Nuclear receptor subfamily 3 group C
Specifications & Purity ExactAb™, Validated, Recombinant, 0.3 mg/mL
Host species Rabbit
Specificity NR3C1
Immunogen Recombinant protein of human Glucocorticoid Receptor (AA 2-149)
Positive Control WB: Ramos, HeLa, A549, A431, RAW 264.7, NIH/3T3 and C6 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Glucocorticoid Receptor Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/1000
Protein Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
Post-translational
Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. Sumoylated; this reduces transcription transactivation. Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Antigen affinity purified
Shape Liquid
Concentration 0.3 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Glucocorticoid Receptor Antibody (Ab105558) - Western Blot
All lanes: Recombinant Glucocorticoid Receptor Antibody (Ab105558) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 86 kDa
Observed band size: 90 kDa
Exposure time: 14.5 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0303288 Certificate of Analysis Mar 15, 2024 Ab105558
ZJ24F0303287 Certificate of Analysis Mar 15, 2024 Ab105558

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