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Recombinant Cullin 4A/CUL-4A Antibody - Primary antibody, specific to Cullin 4A, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab098182
Grouped product items
SKU Size
Availability
 Price Qty
Ab098182-10μl
10μl
2
$59.90
Ab098182-50μl
50μl
1
$179.90
Ab098182-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab098182-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Cullin 4A/CUL-4A Antibody; WB; Unconjugated

View related series
Click to view target information: CUL4A
Accession#: Q13619 (1) CUL4A (1) Cullin 4A (1) Gene ID: 8451 (1)

Basic Description

Product Name Recombinant Cullin 4A/CUL-4A Antibody - Primary antibody, specific to Cullin 4A, Rabbit IgG
Synonyms AW495282 antibody | CUL 4A antibody | CUL-4A antibody | Cul4a antibody | Cul4a protein antibody | CUL4A_HUMAN antibody | Cullin-4A antibody | MGC36573 antibody | MGC64071 antibody | 2810470J21Rik antibody
Specifications & Purity Recombinant, ExactAb™, Validated, High Performance, See COA
Host species Rabbit
Specificity Cullin 4A
Immunogen A synthetic peptide derived from human Cullin 4A (AA 741-754).
Positive Control WB: HeLa, HEK293, A375 and Hep G2 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, High Performance, Recombinant, Validated
Product Description

Rabbit anti Human Cullin 4A/CUL-4A Antibody, Recombinant, could be used for WB and so on.
Application
WB: 1/1000-1/5000
Protein Function
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

CUL4A Tchem Cullin-4A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Cullin 4A/CUL-4A Antibody (Ab098182) - Western Blot
All lanes: Recombinant Cullin 4A/CUL-4A Antibody (Ab098182) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 87 kDa
Observed band size: 84, 90 kDa
Exposure time: 8.7 s

Recombinant Cullin 4A/CUL-4A Antibody (Ab098182) - Western Blot
All lanes: Recombinant Cullin 4A/CUL-4A Antibody (Ab098182) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 87 kDa
Observed band size: 87 kDa
Exposure time: 10.0 s


Application

Application Dilution info
WB

1/1000 - 1/5000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0708394 Certificate of Analysis Jul 17, 2024 Ab098182
ZJ24F0708393 Certificate of Analysis Jul 17, 2024 Ab098182

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