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Recombinant Clusterin Antibody - Primary antibody, specific to Clusterin, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab096938
Grouped product items
SKU Size
Availability
 Price Qty
Ab096938-10μl
10μl
2
$66.90
Ab096938-50μl
50μl
1
$199.90
Ab096938-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab096938-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,499.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Clusterin Antibody; WB; Unconjugated

View related series
Click to view target information: CLU
Accession#:P10909 (3) CLU (3) Clusterin (3) Gene ID:1191 (3)

Basic Description

Product Name Recombinant Clusterin Antibody - Primary antibody, specific to Clusterin, Rabbit IgG
Synonyms 40 antibody | AAG 4 antibody | AAG4 antibody | Aging associated protein 4 antibody | Aging-associated gene 4 protein antibody | AI893575 antibody | APO J antibody | Apo-J antibody | APOJ antibody | ApoJalpha antibody | ApoJbeta antibody | Apolipoprotein J
Specifications & Purity ExactAb™, Validated, Recombinant, 0.1 mg/mL
Host species Rabbit
Specificity Clusterin
Immunogen A synthetic peptide derived from human Clusterin (AA 400-449)
Positive Control WB: Human serum, U-2 OS and HeLa lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Clusterin Antibody, Recombinant, could be used for WB and so on.
Application
WB: 1/500-1/1000
Protein Function
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 0.1 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

CLU Tbio Clusterin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant Clusterin Antibody (Ab096938) - Western Blot
All lanes: Recombinant Clusterin Antibody (Ab096938) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 37, 66 kDa
Exposure time: 32.1 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0505743 Certificate of Analysis May 16, 2024 Ab096938
ZJ24F0505742 Certificate of Analysis May 16, 2024 Ab096938

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