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Recombinant c-Maf Antibody - Primary antibody, specific to MAF, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab096954
Grouped product items
SKU Size
Availability
 Price Qty
Ab096954-10μl
10μl
2
$69.90
Ab096954-50μl
50μl
1
$199.90
Ab096954-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab096954-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human c-Maf Antibody; WB; Unconjugated

View related series
Click to view target information: MAF
Accession#: O75444 (1) c-Maf (1) Gene ID: 4094 (1) MAF (1)

Basic Description

Product Name Recombinant c-Maf Antibody - Primary antibody, specific to MAF, Rabbit IgG
Synonyms Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene antibody | Avian musculoaponeurotic fibrosarcoma (v maf)antibody | c maf proto oncogene antibody | cMaf antibody | maf antibody | MAF_HUMAN antibody | MAF2 antibody | MGC71685 antibody | AS42 oncog
Specifications & Purity Recombinant, ExactAb™, Validated, See COA
Host species Rabbit
Specificity MAF
Immunogen A synthetic peptide derived from human c-Maf (AA 331-362)
Positive Control WB: HeLa, Jurkat, Hep G2, A549, HUVEC, Raji, NIH/3T3 and C6 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human c-Maf Antibody, Recombinant, could be used for WB and so on.
Protein Function
Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glukagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glukagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant reponse element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.
Post-translational
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids. Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable). The phosphorylation status can serve to either stimulate or inhibit transcription.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAF Tbio Transcription factor Maf (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant c-Maf Antibody (Ab096954) - Western Blot
All lanes: Recombinant c-Maf Antibody (Ab096954) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 42 kDa
Observed band size: 45 kDa
Exposure time: 32.9 s

Application

Application Dilution info
WB

1/500-1/2000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0708578 Certificate of Analysis Jul 22, 2024 Ab096954
ZJ24F0708577 Certificate of Analysis Jul 22, 2024 Ab096954

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