Basic Description

Product Name	PARK7 Antibody - Primary antibody, specific to PARK7, Rabbit IgG
Synonyms	CAP1 antibody \| DJ-1 antibody \| DJ1 antibody \| DJ1 proteinantibody \| Epididymis secretory sperm binding protein Li 67p antibody \| FLJ27376 antibody \| FLJ34360 antibody \| FLJ92274 antibody \| HEL S 67p antibody \| Oncogene DJ1 antibody \| OTTHUMP00000001348 a
Specifications & Purity	Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA
Host species	Rabbit
Specificity	PARK7
Immunogen	Recombinant PARK7 expressed in E.coli (AA 1-189).
Positive Control	WB: Jurkat, MCF7, Hep G2, HeLa, HUVEC and NIH/3T3 cell lysates. IHC: Human spleen, kidney, skeletal muscle tissues.
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, High Performance, Validated
Product Description	Rabbit anti Human PARK7 Antibody, Polyclonal antibody, could be used for WB, IHC and so on. Application: WB: 0.01-2 µg/mL IHC: 5-20 µg/mL Protein Function Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Shape	Liquid
Concentration	See COA
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PARK7 Tbio Protein/nucleic acid deglycase DJ-1 (0 Activities)

Discover Target: PARK7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Images

Western Blot: PARK7 Antibody (Ab120346)

PARK7 Antibody (Ab120346) - Western Blot
All lanes: PARK7 Antibody (Ab120346) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 22 kDa
Observed band size: 23 kDa
Exposure time: 15.0 s