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Recombinant Poliovirus Receptor/PVR Antibody - Primary antibody, specific to PVR, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab122570
Grouped product items
SKU Size
Availability
 Price Qty
Ab122570-10μl
10μl
1
$59.90
Ab122570-50μl
50μl
1
$189.90
Ab122570-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab122570-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Poliovirus Receptor/PVR Antibody; WB; Unconjugated

View related series
Click to view target information: PVR
Accession#:P15151 (4) CD155 (3) Gene ID:5817 (4) Poliovirus Receptor (3) PVR (5)

Basic Description

Product Name Recombinant Poliovirus Receptor/PVR Antibody - Primary antibody, specific to PVR, Rabbit IgG
Synonyms CD155 | HVED | NECL5 | Necl-5 | nectin-like 5 | Nectin-like protein 5 | poliovirus receptor | PVR | CD155 antigen | PVS | PVSFLJ25946 | Tage4 | CD155 antibody | CD155 antigen antibody | FLJ25946 antibody | HVED antibody | mE4 antibody | NECL 5 antibody |
Specifications & Purity Recombinant, ExactAb™, KD Validation, Validated, See COA
Host species Rabbit
Specificity PVR
Immunogen A synthetic peptide derived from human Poliovirus Receptor (AA 220-350)
Positive Control WB: A549, HUVEC and HeLa cell lysates.
Conjugation Unconjugated
Grade ExactAb™, KD Validation, Recombinant, Validated
Product Description

Rabbit anti Human Poliovirus Receptor/PVR Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/2000
Protein Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PVR Tbio Poliovirus receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant Poliovirus Receptor/PVR Antibody (Ab122570) - Western Blot
All lanes: Recombinant Poliovirus Receptor/PVR Antibody (Ab122570) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 71 kDa
Exposure time: 150.5 s
Poliovirus Receptor/PVR is a glycoprotein. The molecular weight observed is consistent with what has been described in the literature (PMID:17893876,11454801).

Application

Application Dilution info
WB

1/500-1/2000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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