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Recombinant Lamin A + Lamin C Antibody - Primary antibody, specific to LMNA, Rabbit IgG

COA COA
    Application:
  • IF/ICC
  • IHC
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab112634
Grouped product items
SKU Size
Availability
 Price Qty
Ab112634-10μl
10μl
2
$69.90
Ab112634-50μl
50μl
1
$199.90
Ab112634-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab112634-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Lamin A + Lamin C Antibody; WB, IHC, IF, ICC; Unconjugated

View related series
Click to view target information: LMNA
Accession#:P02545 (5) Gene ID:4000 (5) Lamin A + Lamin C (1) LMNA (5)

Basic Description

Product Name Recombinant Lamin A + Lamin C Antibody - Primary antibody, specific to LMNA, Rabbit IgG
Synonyms Lamin A + Lamin C | Lamin A + C | LMN1 | 70 kDa lamin | CDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LAMIN A | lamin A/C | LAMIN C | LDP1 | LFP | LGMD1B | LMN 1 | LMN A | LMN C | LMNA | LMNC | NY REN 32 antigen | PRO1 | LMNA_HUMAN | Pr
Specifications & Purity ExactAb™, Validated, Recombinant, 0.2 mg/mL
Host species Rabbit
Specificity LMNA
Immunogen A synthetic peptide derived from human Lamin A/C (AA 25-40)
Positive Control WB: HeLa, L929, NIH/3T3 and C6 cell lysates. IHC: Human breast cancer tissue. ICC/IF: HeLa cells.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Lamin A + Lamin C Antibody, Recombinant, could be used for WB, IHC, IF, ICC and so on.

Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
ICC/IF: 1/50-1/200

Protein Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.

Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Antigen affinity purified
Shape Liquid
Concentration 0.2 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

LMNA Tbio Prelamin-A/C (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Lamin A + Lamin C Antibody (Ab112634) - Western Blot
All lanes: Recombinant Lamin A + Lamin C Antibody (Ab112634) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 74 kDa
Observed band size: 63, 71 kDa
Exposure time: 2.2 s

Recombinant Lamin A + Lamin C Antibody (Ab112634) - IF/ICC
Immunocytochemistry analysis of Lamin A/C (green) in HeLa using Recombinant Lamin A + Lamin C Antibody (Ab112634), and cells were counterstained with DAPI (blue).

Recombinant Lamin A + Lamin C Antibody (Ab112634) - IHC
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant Lamin A + Lamin C Antibody (Ab112634). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Application

Application Dilution info
WB

1/500-1/1000
IF/ICC

1/50-1/200

IHC

1/50 - 1/100

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0506089 Certificate of Analysis May 24, 2024 Ab112634
ZJ24F0506088 Certificate of Analysis May 24, 2024 Ab112634

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