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Recombinant H-FABP Antibody

    应用:
  • Capture Antibody
  • CLIA
  • ELISA
  • FIA
  • GICA
  • 宿主种属: 小鼠(Mouse)
  • 种属反应性: 人(Human)
  • 亚型: Mouse IgG1
  • 克隆号: 26H2
  • 偶联: Unconjugated
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab107394-10μg
10μg 现货 Stock Image
Ab107394-50μg
50μg 现货 Stock Image
Ab107394-100μg
100μg 现货 Stock Image
Ab107394-1mg
1mg 期货 Stock Image

基本信息

产品名称 Recombinant H-FABP Antibody
别名 心脏型脂肪酸结合蛋白抗体 | 重组H-FABP抗体
英文别名 422 protein antibody | Cardiac FABP antibody | Cardiac Fatty Acid Binding Protein antibody | FABP 11 antibody | FABP 3 antibody | FABP11 antibody | FABP3 antibody | FABPH_HUMAN antibody | Fatty acid binding protein 11 antibody | Fatty acid binding protein
规格或纯度 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 见COA
宿主种属 小鼠(Mouse)
特异性 Human H-FABP
应用 ELISA,CLIA,GICA,Capture antibody,FIA
种属反应性 人(Human)
免疫原 E. coli-derived recombinant human H-FABP(Met1-Ala133)
偶联 Unconjugated

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
克隆号 26H2
Format Whole IgG
亚型 IgG1
SDS-PAGE 150 kDa
纯化方法 Protein A purified
配对抗体 [Ab007972] Recombinant H-FABP Antibody as detection antibody in ELISA, CLIA
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 10mM PB+150mM NaCl+0.1% ProClin300,pH7.4
防腐剂 0.1% ProClin 300
浓度 见COA
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20±5℃ 下可保存三年。避免冷冻/解冻。
分子类型 抗体

关联靶点(人)

FABP3 Tchem 脂肪酸结合蛋白、心脏(Fatty acid-binding protein, heart) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

H-FABP Standard Curve with Antibody Pair (Ab007972 & Ab107394) in GICA

· Capture antibody: Recombinant FABP3H-FABP Antibody (Ab007972) at 1.0 mg/mL. 

· Detection antibody: Recombinant H-FABP Antibody (Ab107394) at 1.0 mg/mL.

· Linear Range: 0-500 ng/mL.

应用

应用名称 稀释比例
ELISA

1 μg/mL

CLIA

1 μg/mL

FIA

1 mg/mL

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F1012079 分析证书 Ab107394
ZJ23F0500231 分析证书 Ab107394
ZJ23F0500229 分析证书 Ab107394

引用文献

1. Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA.  (2009)  Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins..  J Med Chem,  52  (19): (6024-31).  [PMID:19754198]
2. Young AC, Scapin G, Kromminga A, Patel SB, Veerkamp JH, Sacchettini JC.  (1994)  Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids..  Structure,  (6): (523-34).  [PMID:7922029]
3. Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D et al..  (2011)  New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein..  Bioorg Med Chem Lett,  21  (10): (2949-52).  [PMID:21481589]
4. Haiyan Cai,Guirui Yan,Xiaodong Zhang,Olena Gorbenko,Heyao Wang,Weiliang Zhu.  (2010-05-18)  Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening..  Bioorganic & medicinal chemistry letters,  20  ((12)): (3675-3679).  [PMID:20471252]
5. Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundbäck T, Rondahl L, Barf T..  (2004)  Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target..  Bioorg Med Chem Lett,  14  (17): (4445-4448).  [PMID:15357969] [10.1016/j.bmcl.2004.06.057]
6. Barf T, Lehmann F, Hammer K, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Rondahl L, Lundbäck T..  (2009)  N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors..  Bioorg Med Chem Lett,  19  (6): (1745-1748).  [PMID:19217286] [10.1016/j.bmcl.2009.01.084]
7. Cai H, Liu Q, Gao D, Wang T, Chen T, Yan G, Chen K, Xu Y, Wang H, Li Y, Zhu W..  (2015)  Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination..  Eur J Med Chem,  90  (241-250).  [PMID:25461324] [10.1016/j.ejmech.2014.11.020]
8. Zhou Y, Nie T, Zhang Y, Song M, Li K, Ding M, Ding K, Wu D, Xu Y..  (2016)  The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation..  Bioorg Med Chem,  24  (18): (4310-4317).  [PMID:27460668] [10.1016/j.bmc.2016.07.022]
9. Kühne H, Obst-Sander U, Kuhn B, Conte A, Ceccarelli SM, Neidhart W, Rudolph MG, Ottaviani G, Gasser R, So SS, Li S, Zhang X, Gao L, Myers M..  (2016)  Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors..  Bioorg Med Chem Lett,  26  (20): (5092-5097).  [PMID:27658368] [10.1016/j.bmcl.2016.08.071]
10. Gao DD, Dou HX, Su HX, Zhang MM, Wang T, Liu QF, Cai HY, Ding HP, Yang Z, Zhu WL, Xu YC, Wang HY, Li YX..  (2018)  From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4..  Eur J Med Chem,  154  (44-59).  [PMID:29775936] [10.1016/j.ejmech.2018.05.007]
11. Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I..  (2018)  SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins..  Eur J Med Chem,  154  (233-252).  [PMID:29803996] [10.1016/j.ejmech.2018.04.050]
12. He Y, Dou H, Gao D, Wang T, Zhang M, Wang H, Li Y..  (2019)  Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor..  Bioorg Med Chem,  27  (19): (115015-115015).  [PMID:31420256] [10.1016/j.bmc.2019.07.031]
13. Zanotti, G G, Scapin, G G, Spadon, P P, Veerkamp, J H JH and Sacchettini, J C JC..  (1992)  Three-dimensional structure of recombinant human muscle fatty acid-binding protein..  The Journal of biological chemistry,  (15): [PMID:1526991]
14. Peeters, R A RA, Veerkamp, J H JH, Geurts van Kessel, A A, Kanda, T T and Ono, T T..  (1991)  Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization..  The Biochemical journal,  (15): [PMID:1710107]
15. Börchers, T T and 5 more authors..  (1990)  Revision of the amino acid sequence of human heart fatty acid-binding protein..  Molecular and cellular biochemistry,  [PMID:2266954]
16. Offner, G D GD, Brecher, P P, Sawlivich, W B WB, Costello, C E CE and Troxler, R F RF..  (1988)  Characterization and amino acid sequence of a fatty acid-binding protein from human heart..  The Biochemical journal,  (15): [PMID:3421901]
17. Kovalyov, L I LI and 6 more authors..  (1995)  The major protein expression profile and two-dimensional protein database of human heart..  Electrophoresis,  [PMID:7498159]
18. Troxler, R F RF and 6 more authors..  (1993)  Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33..  Human genetics,  [PMID:8262516]
19. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,  (18): [PMID:16710414]
20. Bienvenut, Willy V WV and 6 more authors..  (2012)  Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features..  Molecular & cellular proteomics : MCP,  [PMID:22223895]

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