SGK - 代谢酶/蛋白酶 - 按“信号通路”分类

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CKI-7 盐酸盐

规格或纯度 :

≥98%(HPLC)

CAS号: 1177141-67-1 Compound CID : 16078955

分子式: C₁₁H₁₂ClN₃O₂S · 2HCl 分子量: 358.67

IUPAC Name: N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride

SMILES: C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl

InChIKey: JUAVTXYOCISSSL-UHFFFAOYSA-N

InChI: 1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H

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EMD638683,SGK1抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 1181770-72-8

分子式: C₁₈H₁₈F₂N₂O₄ 分子量: 364.34

IUPAC Name: N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

SMILES: CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

InChIKey: SSNAPUUWBPZGOY-UHFFFAOYSA-N

InChI: 1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)

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GSK 650394,血清和糖皮质激素调节激酶（SGK）抑制剂

规格或纯度 :

Moligand™

≥97%(HPLC)

CAS号: 890842-28-1

分子式: C₂₅H₂₂N₂O₂ 分子量: 382.45

IUPAC Name: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

SMILES: C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O

InChIKey: WVSBGSNVCDAMCF-UHFFFAOYSA-N

InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

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PROTAC SGK3降解剂-1

规格或纯度 :

≥98%

CAS号: 2381320-35-8 Compound CID : 139035049

分子式: C₅₇H₇₃FN₁₀O₁₁S₂ 分子量: 1157.38

IUPAC Name: (2S,4R)-1-[(2S)-2-[[2-[2-[2-[6-[(2R)-2-[[6-[4-[(2-fluoro-5-methylphenyl)sulfonylamino]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxymethyl]morpholin-4-yl]hexoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbSee more

SMILES: CC1=CC(=C(C=C1)F)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4=C(C=NN4)C(=N3)OCC5CN(CCO5)CCCCCCOCCOCCOCC(=O)NC(C(=O)N6CC(CC6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)C

InChIKey: RTFQFPZKDYMMMJ-RIAKQDHQSA-N

InChI: 1S/C57H73FN10O11S2/c1-37-10-19-46(58)48(28-37)81(73,74)66-42-17-15-41(16-18-42)52-63-53-45(31-61-65-53)55(64-52)79-34-44-33-67(21-23-78-44)20-8-6-7-9-22-75-24-25-76-26-27-77-35-49(70)62-51(57(3,4)5)56See more

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EMD638683

规格或纯度 :

Moligand™

10mM in DMSO

CAS号: 1181770-72-8

分子式: C₁₈H₁₈F₂N₂O₄ 分子量: 364.34

IUPAC Name: N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

SMILES: CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

InChIKey: SSNAPUUWBPZGOY-UHFFFAOYSA-N

InChI: 1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)

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GSK 650394

规格或纯度 :

Moligand™

10mM in DMSO

CAS号: 890842-28-1

分子式: C₂₅H₂₂N₂O₂ 分子量: 382.45

IUPAC Name: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

SMILES: C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O

InChIKey: WVSBGSNVCDAMCF-UHFFFAOYSA-N

InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

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SGK1-IN-2

规格或纯度 :

≥98%

CAS号: 1426214-64-3 Compound CID : 71537261

分子式: C₁₇H₁₂Cl₂N₆O₂S 分子量: 435.29

IUPAC Name: N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide

SMILES: C1=CC(=CC=C1C2=NC3=NNC(=C3N=C2)N)NS(=O)(=O)C4=C(C=CC(=C4)Cl)Cl

InChIKey: RTERCHJCWXQPSS-UHFFFAOYSA-N

InChI: 1S/C17H12Cl2N6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)

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EMD638683 S-Form

规格或纯度 :

≥99%

CAS号: 1184940-46-2

分子式: C₁₈H₁₈F₂N₂O₄ 分子量: 364.34

IUPAC Name: N'-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

SMILES: CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

InChIKey: SSNAPUUWBPZGOY-INIZCTEOSA-N

InChI: 1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)/t16-/m0/s1

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EMD638683 R-Form

规格或纯度 :

≥99%

CAS号: 1184940-47-3

分子式: C₁₈H₁₈F₂N₂O₄ 分子量: 364.34

IUPAC Name: N'-[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

SMILES: CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

InChIKey: SSNAPUUWBPZGOY-MRXNPFEDSA-N

InChI: 1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)/t16-/m1/s1

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SGK1-IN-4

规格或纯度 :

≥97%

CAS号: 1628048-93-0

分子式: C₂₃H₂₁ClFN₅O₄S 分子量: 517.96

SMILES: O=S(NC(C=C1)=CC=C1C2=NC(O[C@@H]3CC[C@H](CC3)O)=C4C(NN=C4)=N2)(C5=C(C=CC(Cl)=C5)F)=O

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SGK1-IN-1

规格或纯度 :

≥99%

CAS号: 1279829-87-6 Compound CID : 71506845

分子式: C₁₇H₁₂ClFN₆O₂S 分子量: 418.83

IUPAC Name: N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide

SMILES: C1=CC(=CC=C1C2=NC3=NNC(=C3N=C2)N)NS(=O)(=O)C4=C(C=CC(=C4)Cl)F

InChIKey: DDKHTWASHUKHLD-UHFFFAOYSA-N

InChI: 1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)

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HaloPROTAC-E

CAS号: 2365478-58-4 Compound CID : 154723985

分子式: C₃₉H₅₆ClN₅O₈S 分子量: 790.4

IUPAC Name: (2S,4R)-N-[[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carSee more

SMILES: CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O)OCCOCCOCCOCCCCCCCl

InChIKey: NJCGXLMTZGCSRS-JSWXEYCZSA-N

InChI: 1S/C39H56ClN5O8S/c1-27-33(54-26-43-27)28-9-10-29(32(21-28)53-20-19-52-18-17-51-16-15-50-14-8-6-5-7-13-40)23-42-35(47)31-22-30(46)24-45(31)36(48)34(38(2,3)4)44-37(49)39(25-41)11-12-39/h9-10,21,26,30-31See more

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