GSK-3 - PI3K/Akt/mTOR 信号通路 - 按“信号通路”分类

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AZD2858,GSK-3抑制剂

规格或纯度 :

Moligand™

≥99%

CAS号: 486424-20-8

分子式: C₂₁H₂₃N₇O₃S 分子量: 453.52

IUPAC Name: 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide

SMILES: CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N

InChIKey: FHCSBLWRGCOVPT-UHFFFAOYSA-N

InChI: 1S/C21H23N7O3S/c1-27-9-11-28(12-10-27)32(30,31)17-6-4-15(5-7-17)18-14-24-20(22)19(26-18)21(29)25-16-3-2-8-23-13-16/h2-8,13-14H,9-12H2,1H3,(H2,22,24)(H,25,29)

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2-羟基-3-[5-[(吗啉-4-基)甲基]吡啶-2-基]-1H-吲哚-5-甲腈(AZD1080)

规格或纯度 :

Moligand™

≥98%

CAS号: 612487-72-6

分子式: C₁₉H₁₈N₄O₂ 分子量: 334.37

IUPAC Name: 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile

SMILES: C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O

InChIKey: BLTVBQXJFVRPFK-UHFFFAOYSA-N

InChI: 1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2

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C24:1 神经酰胺 (d18:1/24:1 (15Z))

规格或纯度 :

≥99%

CAS号: 54164-50-0

分子式: C₄₂H₈₁NO₃ 分子量: 648.10

IUPAC Name: (Z)-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracos-15-enamide

SMILES: CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCCCCCCCCCCC=CCCCCCCCC)O

InChIKey: VJSBNBBOSZJDKB-KPEYJIHVSA-N

InChI: 1S/C42H81NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,35,37,40-41,44-45H,3-16,19-34,36,38-39H2,1-2H3,(H,See more

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R547,cdk抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 741713-40-6 Compound CID : 6918852

分子式: C₁₈H₂₁F₂N₅O₄S 分子量: 441.45

IUPAC Name: [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone

SMILES: COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C

InChIKey: JRNJNYBQQYBCLE-UHFFFAOYSA-N

InChI: 1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)

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SB216763,GSK3抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 280744-09-4 Compound CID : 176158

分子式: C₁₉H₁₂N₂O₂Cl₂ 分子量: 371.22

IUPAC Name: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione

SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl

InChIKey: JCSGFHVFHSKIJH-UHFFFAOYSA-N

InChI: 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

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SB 415286,GSK3抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 264218-23-7 Compound CID : 4210951

分子式: C₁₆H₁₀ClN₃O₅ 分子量: 359.72

IUPAC Name: 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione

SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

InChIKey: PQCXVIPXISBFPN-UHFFFAOYSA-N

InChI: 1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

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TWS119,细胞渗透性GSK-3β抑制剂

规格或纯度 :

Moligand™

≥95%

CAS号: 601514-19-6 Compound CID : 9549289

分子式: C₁₈H₁₄N₄O₂ 分子量: 318.33

IUPAC Name: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

SMILES: C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O

InChIKey: VPVLEBIVXZSOMQ-UHFFFAOYSA-N

InChI: 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)

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Tideglusib,非ATP竞争性GSK-3β抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 865854-05-3 Compound CID : 11313622

分子式: C₁₉H₁₄N₂O₂S 分子量: 334.39

IUPAC Name: 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione

SMILES: C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43

InChIKey: PMJIHLSCWIDGMD-UHFFFAOYSA-N

InChI: 1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2

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4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

规格或纯度 :

Moligand™

≥98%

CAS号: 327036-89-5 Compound CID : 4124851

分子式: C₁₀H₁₀N₂O₂S 分子量: 222.26

IUPAC Name: 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

SMILES: CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2

InChIKey: JDSJDASOXWCHPN-UHFFFAOYSA-N

InChI: 1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

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(2'Z,3'E)-6-溴靛玉红-3'-肟

规格或纯度 :

Moligand™

≥98%

CAS号: 667463-62-9

分子式: C₁₆H₁₀BrN₃O₂ 分子量: 356.17

IUPAC Name: 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol

SMILES: C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O

InChIKey: SAQUSDSPQYQNBG-UHFFFAOYSA-N

InChI: 1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H

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CHIR-99021,GSK-3抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 252917-06-9

分子式: C₂₂H₁₈Cl₂N₈ 分子量: 465.34

IUPAC Name: 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile

SMILES: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

InChIKey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N

InChI: 1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)

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头孢曲松钠 3.5水合物

规格或纯度 :

≥98%

CAS号: 104376-79-6 EC号: 277-930-0 Compound CID : 11953897

分子式: C₁₈H₁₆N₈Na₂O₇S₃ · 3.5H₂O 分子量: 661.58

IUPAC Name: tetrasodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylSee more

SMILES: CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]

InChIKey: KTAVBOYXMBQFGR-MAODNAKNSA-J

InChI: 1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)See more

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