NEDD8活化酶 - 代谢酶/蛋白酶 - 按“信号通路”分类

MLN4924,NEDD8活化酶抑制剂

规格或纯度 :

≥98%

CAS号: 905579-51-3

分子式: C₂₁H₂₅N₅O₄S 分子量: 443.53

IUPAC Name: [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate

SMILES: C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N

InChIKey: MPUQHZXIXSTTDU-QXGSTGNESA-N

InChI: 1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/See more

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NAcM-OPT

规格或纯度 :

≥99%

CAS号: 2089293-61-6

分子式: C₂₃H₂₉Cl₂N₃O 分子量: 434.4

IUPAC Name: 1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

SMILES: CCCCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)Cl)Cl

InChIKey: VPHJABWIKCBGMC-UHFFFAOYSA-N

InChI: 1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)

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TAS4464

规格或纯度 :

≥98%

CAS号: 1848959-10-3 Compound CID : 124121703

分子式: C₂₁H₂₃FN₆O₆S 分子量: 506.51

IUPAC Name: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]oxolan-2-yl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidine

SMILES: CCOC1=C(C(=CC=C1)F)C#CC2=CN(C3=NC=NC(=C23)N)C4C(C(C(O4)CNS(=O)(=O)N)O)O

InChIKey: TZTRUHFXPVXWRD-QTQZEZTPSA-N

InChI: 1S/C21H23FN6O6S/c1-2-33-14-5-3-4-13(22)12(14)7-6-11-9-28(20-16(11)19(23)25-10-26-20)21-18(30)17(29)15(34-21)8-27-35(24,31)32/h3-5,9-10,15,17-18,21,27,29-30H,2,8H2,1H3,(H2,23,25,26)(H2,24,31,32)/t15-,1See more

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NAcM-OPT

规格或纯度 :

10mM in DMSO

CAS号: 2089293-61-6

分子式: C₂₃H₂₉Cl₂N₃O 分子量: 434.4

IUPAC Name: 1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

SMILES: CCCCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)Cl)Cl

InChIKey: VPHJABWIKCBGMC-UHFFFAOYSA-N

InChI: 1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)

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TAS4464 hydrochloride

规格或纯度 :

≥98%

CAS号: 1848959-11-4 Compound CID : 124121823

分子式: C₂₁H₂₄ClFN₆O₆S 分子量: 542.97

IUPAC Name: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]oxolan-2-yl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidine;hydrochloride

SMILES: CCOC1=C(C(=CC=C1)F)C#CC2=CN(C3=NC=NC(=C23)N)C4C(C(C(O4)CNS(=O)(=O)N)O)O.Cl

InChIKey: CDCFJYCKNAWPTL-WVAMHNCPSA-N

InChI: 1S/C21H23FN6O6S.ClH/c1-2-33-14-5-3-4-13(22)12(14)7-6-11-9-28(20-16(11)19(23)25-10-26-20)21-18(30)17(29)15(34-21)8-27-35(24,31)32;/h3-5,9-10,15,17-18,21,27,29-30H,2,8H2,1H3,(H2,23,25,26)(H2,24,31,32);1See more

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Pevonedistat hydrochloride

规格或纯度 :

≥99%

CAS号: 1160295-21-5 Compound CID : 66576990

分子式: C₂₁H₂₆ClN₅O₄S 分子量: 480

IUPAC Name: [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate;hydrochloride

SMILES: C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N.Cl

InChIKey: HJKDNNXKYODZJI-BVMPOVDASA-N

InChI: 1S/C21H25N5O4S.ClH/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18;/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25);1H/t14-,15+,18-See more

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