标准化的活性类型和单位

发布于 2024年9月6日更新时间 2024年9月6日

下表存储了标准化活性类型和单位的详细信息，以及允许的值范围。用于确定一系列已发布类型/单位的正确标准类型和标准单位。

序号	标准类型	中文定义	英文定义	标准单位	正常范围最小值	正常范围最大值
1	CC50	达到 50% 细胞毒性所需的浓度	Concentration required for 50% cytotoxicity	nM	1	10000000
2	EC50	50%活性的有效浓度	Effective concentration for 50% activity	nM	0.01	100000
3	GI50	50% 生长抑制所需的浓度	Concentration required for 50% growth inhibition	nM	1	10000000
4	IC50	50% 抑制所需的浓度	Concentration required for 50% inhibition	nM	0.01	100000
5	Ki	抑制常数	Inhibition constant	nM	0.01	100000
6	Solubility	溶解度	Solubility	nM	100	1000000000
7	Solubility	溶解度	Solubility	ug.mL-1	0.05	50000
8	T1/2	半衰期	Half-life	hr	0.001	10000
9	CL	清除	Clearance	mL.min-1.g-1	0	10000
10	CL	清除	Clearance	mL.min-1.kg-1	0	10000
11	CL_renal	肾脏清除率	Renal clearance	mL.min-1.kg-1	0	10000
12	CL/F	清除率/生物利用度	Clearance/Bioavailability	mL.min-1.kg-1	0	10000
13	CLogD	计算对数（分布系数）	Calculated Log(Distribution Coefficient)	-	-10	15
14	CLogD7.4	pH7.4 时计算的对数（分配系数）	Calculated Log(Distribution Coefficient) at pH7.4	-	-10	15
15	CLogP	计算对数（分配系数）	Calculated Log(Partition Coefficient)	-	-10	15
16	F	生物利用度	Bioavailability	%	0	150
17	IC95	95% 抑制所需的浓度	Concentration required for 95% inhibition	nM	0.01	100000
18	IFI	抑制频率（滥交）指数	Inhibition Frequency (promiscuity) Index	%	0	100
19	Inhibition	抑制	Inhibition	%	-10	150
20	LogP	对数（分配系数）	Log(Partition Coefficient)	-	-10	15
21	LogPapp	Log（表观渗透率）	Log(Apparent permeability)	-	-10	15
22	Tmax	最大浓度时间	Time for maximum concentration	hr	0.01	1000
23	Vd	分布容积	Volume of Distribution	L.kg-1	0.01	1000
24	Vdss	稳态分布容积	Steady State Volume of Distribution	L.kg-1	0.01	1000
25	XC50	达到 50% 效果所需的浓度	Concentration required for 50% effect	nM	0.01	100000
26	Vd/F	非静脉给药后的分布容积	Volume of distribution after non-intravenous administration	L.kg-1	0.01	1000
27	Cmax	最大浓度	Maximum concentration	ug.mL-1	0.0005	5000
28	Cmax	最大浓度	Maximum concentration	nM	1	10000000
29	IC50	50% 抑制所需的浓度	Concentration required for 50% inhibition	ug.mL-1	0.000005	50
30	MRT	平均停留时间	Mean residence time	hr	0.01	1000
31	IC90	90% 抑制所需的浓度	Concentration required for 90% inhibition	nM	0.01	100000
32	IC90	90% 抑制所需的浓度	Concentration required for 90% inhibition	ug.mL-1	0.000005	50
33	MCC	最低细胞毒浓度	Minimum cytotoxic concentration	nM	1	10000000
34	MCC	最低细胞毒浓度	Minimum cytotoxic concentration	ug.mL-1	0.0005	5000
35	MIC	最低抑菌浓度	Minimum inhibitory concentration	nM	1	10000000
36	MIC	最低抑菌浓度	Minimum inhibitory concentration	ug.mL-1	0.0005	5000
37	Kd	解离常数	Dissociation constant	nM	0.01	100000
38	Vdss/F	非静脉给药后稳态分布容积	Volume of distribution at steady state after non-intravenous administration	L.kg-1	0.01	1000
39	CC50	达到 50% 细胞毒性所需的浓度	Concentration required for 50% cytotoxicity	ug.mL-1	0.0005	5000
40	EC50	50%活性的有效浓度	Effective concentration for 50% activity	ug.mL-1	0.000005	50
41	GI50	50% 生长抑制所需的浓度	Concentration required for 50% growth inhibition	ug.mL-1	0.0005	5000
42	IC99	99% 抑制所需的浓度	Concentration required for 99% inhibition	nM	0.01	100000
43	IC99	99% 抑制所需的浓度	Concentration required for 99% inhibition	ug.mL-1	0.000005	50
44	LC50	达到 50% 致死率所需的浓度	Concentration required for 50% lethality	nM	1	10000000
45	LC50	达到 50% 致死率所需的浓度	Concentration required for 50% lethality	ug.mL-1	0.0005	5000
46	TGI	完全生长抑制所需的浓度	Concentration required for total growth inhibition	nM	1	10000000
47	TGI	完全生长抑制所需的浓度	Concentration required for total growth inhibition	ug.mL-1	0.0005	5000
48	LD50	达到 50% 致死率所需剂量	Dose required for 50% lethality	mg.kg-1	0.0005	5000
49	LD50	达到 50% 致死率所需剂量	Dose required for 50% lethality	umol.kg-1	0.001	10000
50	Km	米氏常数	Michaelis constant	nM	10	100000000
51	Potency	引起特定反应所需的浓度或剂量	Concentration or dose required to elicit a specific response	nM	1	10000000
52	AC50	达到 50% 活性所需的浓度	Concentration required for 50% activity	nM	0.01	100000
53	ED50	50%活性的有效剂量	Effective dose for 50% activity	mg.kg-1	0.0005	500
54	IZ	抑菌圈	Zone of inhibition	mm	0	50
55	MIC50	50% 人群的最低抑制浓度	Minimum inhibitory concentration in 50% of population	nM	1	10000000
56	MIC80	80% 人群的最低抑菌浓度	Minimum inhibitory concentration in 80% of population	nM	1	10000000
57	MIC90	90% 人群的最低抑菌浓度	Minimum inhibitory concentration in 90% of population	nM	1	10000000
58	MIC50	50% 人群的最低抑制浓度	Minimum inhibitory concentration in 50% of population	ug.mL-1	0.0005	5000
59	MIC80	80% 人群的最低抑菌浓度	Minimum inhibitory concentration in 80% of population	ug.mL-1	0.0005	5000
60	MIC90	90% 人群的最低抑菌浓度	Minimum inhibitory concentration in 90% of population	ug.mL-1	0.0005	5000
61	MIC70	70% 人群的最低抑制浓度	Minimum inhibitory concentration in 70% of population	ug.mL-1	0.0005	5000
62	ID50	抑制 50% 所需剂量	Dose required for 50% inhibition	mg.kg-1	0.0005	500
63	ID50	抑制 50% 所需剂量	Dose required for 50% inhibition	umol.kg-1	0.001	1000
64	ED50	50%活性的有效剂量	Effective dose for 50% activity	umol.kg-1	0.001	1000
65	k_obs	观测到的速率常数	Observed rate constant	s-1	0.000001	100000
66	k_on	结合速率常数	Association rate constant	M-1.s-1	1	10000000
67	k_off	解离速率常数	Dissociation rate constant	s-1	0.000001	1000
68	CK	对生物样本中总肌酸激酶的测量。	A measurement of the total creatine kinase in a biological specimen.	U.L-1
69	PT	评估凝血外在途径的血液凝固测量。	A blood clotting measurement that evaluates the extrinsic pathway of coagulation.	s
70	ALB	对生物样本中白蛋白的测量。	A measurement of the albumin protein in a biological specimen.	ug.mL-1
71	ALP	生物样本中碱性磷酸酶的测量。	A measurement of the alkaline phosphatase in a biological specimen.	U.L-1
72	ALP	生物样本中碱性磷酸酶的测量。	A measurement of the alkaline phosphatase in a biological specimen.	IU.L-1
73	ALT	生物样本中丙氨酸氨基转移酶的测量。	A measurement of the alanine aminotransferase in a biological specimen.	U.L-1
74	ALT	生物样本中丙氨酸氨基转移酶的测量。	A measurement of the alanine aminotransferase in a biological specimen.	IU.L-1
75	AST	生物样本中天冬氨酸氨基转移酶的测量。	A measurement of the aspartate aminotransferase in a biological specimen.	U.L-1
76	AST	生物样本中天冬氨酸氨基转移酶的测量。	A measurement of the aspartate aminotransferase in a biological specimen.	IU.L-1
77	BUN	血液样本中尿素氮的测量。	A measurement of the urea nitrogen in a blood specimen.	ug.mL-1
78	CO2	对生物样本中二氧化碳气体的测量。	A measurement of the carbon dioxide gas in a biological specimen.	nM
79	EOS	对生物样本中嗜酸性粒细胞的测量。	A measurement of the eosinophils in a biological specimen.	cells.uL-1
80	GGT	对生物样本中的γ谷氨酰转移酶的测量。	A measurement of the gamma glutamyl transferase in a biological specimen.	IU.L-1
81	HCT	全血样本中由红细胞（红血球）组成的百分比。	The percentage of a whole blood specimen that is composed of red blood cells (erythrocytes).	%
82	HGB	对生物样本中血红蛋白的测量。	A measurement of the hemoglobin in a biological specimen.	ug.mL-1
83	LDH	生物样本中乳酸脱氢酶的测量。	A measurement of the lactate dehydrogenase in a biological specimen.	U.L-1
84	LDH	生物样本中乳酸脱氢酶的测量。	A measurement of the lactate dehydrogenase in a biological specimen.	IU.L-1
85	LYM	对生物样本中淋巴细胞的测量。	A measurement of the lymphocytes in a biological specimen.	cells.uL-1
86	MCH	对生物样本中每个红细胞中血红蛋白平均含量的定量测量。	A quantitative measurement of the mean amount of hemoglobin per erythrocyte in a biological specimen.	pg
87	MCV	对生物样本中红细胞平均体积的定量测量。	A quantitative measurement of the mean volume of erythrocytes in a biological specimen.	fL
88	RBC	对生物样本中红细胞总数的测量。	A measurement of the total erythrocytes in a biological specimen.	cells.uL-1
89	WBC	对生物样本中白细胞的测量。	A measurement of the leukocytes in a biological specimen.	cells.uL-1
90	APTT	测量试剂加入血浆样本后凝固所需时间。由于反应混合物中缺乏组织因子（因子 III），因此该测试不完整。	A measurement of the length of time that it takes for clotting to occur when reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture.	s
91	BASO	对生物样本中嗜碱性粒细胞的测量。	A measurement of the basophils in a biological specimen.	cells.uL-1
92	BILI	对生物样本中总胆红素的测量。	A measurement of the total bilirubin in a biological specimen.	ug.mL-1
93	CHOL	对生物样本中胆固醇的测量。	A measurement of the cholesterol in a biological specimen.	ug.mL-1
94	GLUC	对生物样本中葡萄糖的测量。	A measurement of the glucose in a biological specimen.	ug.mL-1
95	MCHC	对特定体积的生物样本中每个红细胞中血红蛋白平均量的定量测量。	A quantitative measurement of the mean amount of hemoglobin per erythrocytes in a specified volume of a biological specimen.	%
96	MCHC	对特定体积的生物样本中每个红细胞中血红蛋白平均量的定量测量。	A quantitative measurement of the mean amount of hemoglobin per erythrocytes in a specified volume of a biological specimen.	ug.mL-1
97	MONO	对生物样本中的单核细胞进行测量。	A measurement of the monocytes in a biological specimen.	cells.uL-1
98	PHOS	生物样本中磷酸盐的测量。	A measurement of the phosphate in a biological specimen.	ug.mL-1
99	PLAT	对生物样本中的血小板（无核血栓细胞）的测量。	A measurement of the platelets (non-nucleated thrombocytes) in a biological specimen.	cells.uL-1
100	PROT	对生物样本中由一个或多个 α-L-氨基酸链组成的一组复杂有机大分子的测量。	A measurement of a group of complex organic macromolecules composed of one or more alpha-L-amino acid chains in a biological specimen.	ug.mL-1
101	TRIG	生物样本中甘油三酯的测量。	A measurement of the triglycerides in a biological specimen.	ug.mL-1
102	CREAT	对生物样本中的肌酐进行测量。	A measurement of the creatinine in a biological specimen.	ug.mL-1
103	EOSLE	生物样本中嗜酸性粒细胞与白细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of the eosinophils to leukocytes in a biological specimen.	%
104	LYMLE	生物样本中淋巴细胞与白细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of the lymphocytes to leukocytes in a biological specimen.	%
105	URATE	对生物样本中的尿酸进行测量。	A measurement of the urate in a biological specimen.	ug.mL-1
106	BASOLE	生物样本中嗜碱性粒细胞与白细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of the basophils to leukocytes in a biological specimen.	%
107	BILDIR	对生物样本中结合胆红素或水溶性胆红素的测量。	A measurement of the conjugated or water-soluble bilirubin in a biological specimen.	ug.mL-1
108	LIPASE	生物样本中胰脂肪酶的测量。	A measurement of the pancreatic lipase in a biological specimen.	U.L-1
109	MONOLE	生物样本中单核细胞与白细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of the monocytes to leukocytes in a biological specimen.	%
110	NEUTLE	生物样本中中性粒细胞与白细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of the neutrophils to leukocytes in a biological specimen.	%
111	NEUTSG	对生物样本中分叶中性粒细胞的测量。	A measurement of the segmented neutrophils in a biological specimen.	cells.uL-1
112	RBCNUC	对生物样本中有核红细胞（大型、未成熟的有核红细胞）的测量。	A measurement of the nucleated erythrocytes (large, immature nucleated erythrocytes) in a biological specimen.	/100WBC
113	SODIUM	生物样本中钠的测量。	A measurement of the sodium in a biological specimen.	mEq.L-1
114	TERMBW	受试者在特定终点时的体重。（NCI）	The weight of a subject at a specified end point. (NCI)	g
115	WEIGHT	由于重力作用，物体所施加的垂直力。（NCI）	The vertical force exerted by a mass as a result of gravity. (NCI)	g
116	ALBGLOB	生物样本中白蛋白与球蛋白的比例。	The ratio of albumin to globulin in a biological specimen.	-
117	CALCIUM	对生物样本中钙含量的测量。	A measurement of the calcium in a biological specimen.	ug.mL-1
118	FIBRINO	对生物样本中纤维蛋白原的测量。	A measurement of the fibrinogen in a biological specimen.	ug.mL-1
119	PHOSLPD	对生物样本中磷脂的测量。	A measurement of the phospholipids in a biological specimen.	ug.mL-1
120	RETIRBC	生物样本中网织红细胞与红细胞的相对测量值（比率或百分比）。	A relative measurement (ratio or percentage) of reticulocytes to erythrocytes in a biological specimen.	%
121	CHLORIDE	生物样本中氯化物的测量。	A measurement of the chloride in a biological specimen.	mEq.L-1
122	POTASSIUM	生物样本中钾含量的测量。	A measurement of the potassium in a biological specimen.	mEq.L-1
124	AUC	药物浓度时间曲线下面积	Area under the drug concentration time curve	uM.hr	0.001	10000
127	AUC	药物浓度时间曲线下面积	Area under the drug concentration time curve	ng.hr.mL-1	10	10000000
130	fAUC	游离药物浓度时间曲线下面积	Area under the free drug concentration time curve	uM.hr	0.001	10000
134	fAUC	游离药物浓度时间曲线下面积	Area under the free drug concentration time curve	ng.hr.mL-1	10	10000000
135	CL	清除	Clearance	uL.min-1.(10^6cells)-1	0.1	500
136	Compound recovery	血浆、组织或排泄物中特定化合物（例如母体或代谢物）的回收，例如作为绝对或定性测量、回收剂量的百分比	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, percentage of dose recovered	ng.eq.g-1
137	Radiolabel recovery	服用放射性标记化合物后，血浆、组织或排泄物中放射性的恢复，以绝对测量值或剂量百分比表示	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	ng.eq.g-1
138	Compound recovery	血浆、组织或排泄物中特定化合物（例如母体或代谢物）的回收，例如作为绝对或定性测量、回收剂量的百分比	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, percentage of dose recovered	ng.eq.mL-1
139	Radiolabel recovery	服用放射性标记化合物后，血浆、组织或排泄物中放射性的恢复，以绝对测量值或剂量百分比表示	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	ng.eq.mL-1
140	Compound recovery	血浆、组织或排泄物中特定化合物（例如母体或代谢物）的回收，例如作为绝对或定性测量，或回收剂量的百分比	Recovery of a specific compound (e.g. parent or metabolite) in plasma, tissue or excreta, e.g. as absolute or qualitative measurement, or percentage of dose recovered	%
141	Radiolabel recovery	服用放射性标记化合物后，血浆、组织或排泄物中放射性的恢复，以绝对测量值或剂量百分比表示	Recovery of radioactivity in plasma, tissue or excreta after administration of radiolabelled compound, as absolute measurement or percentage of dose	%
142	AUC	药物浓度时间曲线下面积	Area under the drug concentration time curve	ng.hr.g-1
143	Cmax	最大浓度	Maximum concentration	ug.g-1
144	Log S	溶解度对数	Log of solubility	-
145	Kb	平衡结合常数	Equilibrium binding constant	nM	0.01	100000
146	LogD	Log（分布系数）	Log(Distribution Coefficient)	-	-10	15
147	LogD7.4	pH 7.4 时的 Log（分配系数）	Log(Distribution Coefficient) at pH 7.4	-	-10	15
148	Delta Tm	熔化温度的变化	Change in melting temperature	degrees C
149	Fu	未结合化合物的比例	Fraction of compound unbound	-	0	1
150	PPB	血浆蛋白结合率（结合率）	Plasma protein binding as %bound	%	0	105
152	DOSE	所施用物质的量	Amount of a substance administered	mg.kg-1
153	TIME	进行实验干预的点，例如，物质的剂量、样品的测量	Point at which an experimental intervention is performed e.g., dosing of a substance, measuring a sample	hr
154	LogD5.0	pH 5.0 时的 Log（分配系数）	Log(Distribution Coefficient) at pH 5.0	-	-10	15
155	LogD6.5	pH 值为 6.5 时的 Log（分配系数）	Log(Distribution Coefficient) at pH 6.5	-	-10	15
156	LogD5.5	pH 5.5 时的 Log（分配系数）	Log(Distribution Coefficient) at pH 5.5	-	-10	15
159	APDc	标准化动作电位持续时间 (APD) 定义为：APD (ms)/心跳间隔的立方根 (ms)	Normalised action potential duration (APD) defined as: APD (ms) / cube root of Beat Interval (ms)	-
160	FPDc	归一化场电位持续时间 (FPD) 定义为：FPD (ms) / 心跳间隔的立方根 (ms)	Normalised field potential duration (FPD) defined as: FPD (ms) / cube root of Beat Interval (ms)	-
161	Stability	化合物的化学或代谢稳定性的测量。	A measurement of the chemical or metabolic stability of the compound.	%

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