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CD23 Mouse mAb

    应用:
  • Flow Cytometry
  • 宿主种属: 小鼠(Mouse)
  • 种属反应性: 人(Human)
  • 亚型: Mouse IgG1
  • 克隆号: EBVCS-5
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab094310-10μg
10μg 现货 Stock Image
Ab094310-50μg
50μg 现货 Stock Image
Ab094310-100μg
100μg 现货 Stock Image
Ab094310-1mg
1mg 期货 Stock Image

基本信息

产品名称 CD23 Mouse mAb
别名 CD23/FcεRII单克隆抗体 | CD23抗体 | Anti-CD23抗体 | CD23小鼠单克隆抗体 | CD23小鼠单抗
英文别名 BLAST-2 | CD23 | CD23A | CD23CD23 antigen | CLEC4J | CLEC4JC-type lectin domain family 4 member J | C-type lectin domain family 4, member J | Fc epsilon RII | Fc fragment of IgE, low affinity II, receptor for (CD23) | FCE2Fc fragment of IgE, low affinity
规格或纯度 无载体, ExactAb™, 无叠氮钠, 已验证, 见COA
宿主种属 小鼠(Mouse)
特异性 CD23
种属反应性 人(Human)
免疫原 Recombinant protein of human CD23
阳性对照 Flow: Human peripheral blood lymphocytes.
偶联 Unconjugated

产品属性

克隆类型 单克隆抗体
克隆号 EBVCS-5
Format Whole IgG
亚型 Mouse IgG1
轻链亚型 kappa
SDS-PAGE 150 kDa
纯化方法 Protein G purified
物理外观 Liquid
储存缓冲液 10mM PBS, pH 7.2-7.4
防腐剂 No
浓度 见COA
储存温度 2-8°C储存
运输条件 冰袋运输
稳定性与储存 4°C 下运输。4°C 长期保存(12 个月)。收货后建议分装。
分子类型 抗体

关联靶点(人)

FCER2 Tchem 低亲和力免疫球蛋白 ε Fc 受体(Low affinity immunoglobulin epsilon Fc receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

CD23 Mouse mAb (Ab094310) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD23 with CD23 Mouse mAb (Ab094310) conjugated with biotin (right panel) at 0.1 μg/mL for 1 hour at 4°C, compared with mouse IgG (Ab170221) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

CD23 Mouse mAb (Ab094310) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD23 (red) with CD23 Mouse mAb (Ab094310) conjugated with biotin at 0.1 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, mouse IgG (Ab170221) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

CD23 Mouse mAb (Ab094310) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD23 (red) with CD23 Mouse mAb (Ab094310) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (AF647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

应用

应用名称 稀释比例
Flow Cytometry

1μg/100w cells

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F0404405 分析证书 Ab094310
ZJ24F0404406 分析证书 Ab094310
ZJ24F0404407 分析证书 Ab094310

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引用文献

1. Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T.  (1988)  Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression..  Cell,  55  (4): (611-8).  [PMID:2972386]
2. Rose, K K and 8 more authors..  (1992)  Partial characterization of natural and recombinant human soluble CD23..  The Biochemical journal,  (15): [PMID:1417742]
3. Pirron, U U, Schlunck, T T, Prinz, J C JC and Rieber, E P EP..  (1990)  IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE..  European journal of immunology,  [PMID:2167225]
4. Kikutani, H H and 9 more authors..  (1986)  Molecular structure of human lymphocyte receptor for immunoglobulin E..  Cell,  (5): [PMID:2877743]
5. Ikuta, K K and 7 more authors..  (1987)  Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:2949326]
6. Lüdin, C C and 8 more authors..  (1987)  Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor..  The EMBO journal,  [PMID:3034567]
7. Vouldoukis, I I and 7 more authors..  (1995)  The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen..  Proceedings of the National Academy of Sciences of the United States of America,  (15): [PMID:7544003]
8. Padlan, E A EA and Helm, B A BA..  (1993)  Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)..  Receptor,  [PMID:8142907]
9. Bajorath, J J and Aruffo, A A..  (1996)  Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models..  Protein science : a publication of the Protein Society,  [PMID:8745401]
10. Grimwood, Jane J and 97 more authors..  (2004)  The DNA sequence and biology of human chromosome 19..  Nature,  (1): [PMID:15057824]
11. Hibbert, Richard G RG and 9 more authors..  (2005)  The structure of human CD23 and its interactions with IgE and CD21..  The Journal of experimental medicine,  (19): [PMID:16172256]
12. Wurzburg, Beth A BA, Tarchevskaya, Svetlana S SS and Jardetzky, Theodore S TS..  (2006)  Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding..  Structure (London, England : 1993),  [PMID:16765898]
13. Lemieux, George A GA and 9 more authors..  (2007)  The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10..  The Journal of biological chemistry,  (18): [PMID:17389606]
14. Pathan, Nuzhat I NI and 5 more authors..  (2008)  Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines..  Blood,  (1): [PMID:18032710]
15. Ivaldi, Corinne C and 6 more authors..  (2012)  Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23..  PloS one,  [PMID:22615937]
16. Hersheson, Joshua J and 17 more authors..  (2013)  Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia..  Annals of neurology,  [PMID:23424103]

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