货号 (SKU)

包装规格

是否现货

价格

数量

Ab177879-100μg

100μg

现货

Ab177879-1mg

1mg

现货

Ab177879-5mg

5mg

现货

Ab177879-10mg

10mg

期货

基本信息

产品名称	Lumiliximab (anti-FceR2), 免疫球蛋白epsilon Fc 受体拮抗剂
别名	鲁米利昔单抗(抗 FceR2)
英文别名	BLAST-2 \| C-type lectin domain family 4 member J \| Fc-epsilon-RII \| Immunoglobulin E-binding factor \| Lymphocyte IgE receptor
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	FCER2
种属反应性	人(Human)
偶联	Unconjugated
作用类型	拮抗剂
作用机制	免疫球蛋白epsilon Fc 受体拮抗剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.1 kDa (Light Chain) & 53.5 kDa (Heavy Chain), under reducing conditions; 181.0kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	357613-86-6
分子类型	抗体

关联靶点（人）

FCER2 Tchem 低亲和力免疫球蛋白 ε Fc 受体(Low affinity immunoglobulin epsilon Fc receptor) (0 活性数据)

点击查看靶蛋白信息： FCER2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Lumiliximab (anti-FceR2) (Ab177879)

Lumiliximab (anti-FceR2) (Ab177879) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling FceR2 (red) with Lumiliximab (anti-FceR2) (Ab177879). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Lumiliximab (anti-FceR2) (Ab177879)

Lumiliximab (anti-FceR2) (Ab177879) - SEC
The purity of Lumiliximab (anti-FceR2) (Ab177879) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

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找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101620	分析证书	Ab177879
ZJ23F1101621	分析证书	Ab177879
ZJ24F0911494	分析证书	Ab177879
ZJ24F0911493	分析证书	Ab177879
ZJ24F0911492	分析证书	Ab177879

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引用文献

1. Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T. (1988) Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.. Cell, 55 (4): (611-8). [PMID:2972386]
2. Rose, K K and 8 more authors.. (1992) Partial characterization of natural and recombinant human soluble CD23.. The Biochemical journal, (15): [PMID:1417742]
3. Pirron, U U, Schlunck, T T, Prinz, J C JC and Rieber, E P EP.. (1990) IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.. European journal of immunology, [PMID:2167225]
4. Kikutani, H H and 9 more authors.. (1986) Molecular structure of human lymphocyte receptor for immunoglobulin E.. Cell, (5): [PMID:2877743]
5. Ikuta, K K and 7 more authors.. (1987) Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2949326]
6. Lüdin, C C and 8 more authors.. (1987) Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor.. The EMBO journal, [PMID:3034567]
7. Vouldoukis, I I and 7 more authors.. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7544003]
8. Padlan, E A EA and Helm, B A BA.. (1993) Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23).. Receptor, [PMID:8142907]
9. Bajorath, J J and Aruffo, A A.. (1996) Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.. Protein science : a publication of the Protein Society, [PMID:8745401]
10. Hibbert, Richard G RG and 9 more authors.. (2005) The structure of human CD23 and its interactions with IgE and CD21.. The Journal of experimental medicine, (19): [PMID:16172256]
11. Wurzburg, Beth A BA, Tarchevskaya, Svetlana S SS and Jardetzky, Theodore S TS.. (2006) Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.. Structure (London, England : 1993), [PMID:16765898]
12. Lemieux, George A GA and 9 more authors.. (2007) The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.. The Journal of biological chemistry, (18): [PMID:17389606]
13. Pathan, Nuzhat I NI and 5 more authors.. (2008) Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines.. Blood, (1): [PMID:18032710]
14. Ivaldi, Corinne C and 6 more authors.. (2012) Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.. PloS one, [PMID:22615937]
15. Hersheson, Joshua J and 17 more authors.. (2013) Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia.. Annals of neurology, [PMID:23424103]

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Lumiliximab (anti-FceR2), 免疫球蛋白epsilon Fc 受体拮抗剂

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基本信息

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关联靶点（人）

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

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Lumiliximab (anti-FceR2), 免疫球蛋白epsilon Fc 受体拮抗剂

库存信息

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基本信息

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关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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复溶计算器