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Recombinant Mad2L2/REV7 Antibody - Primary antibody, specific to MAD2L2, Rabbit IgG

COA COA
    Application:
  • IF/ICC
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab113958
Grouped product items
SKU Size
Availability
 Price Qty
Ab113958-10μl
10μl
2
$89.90
Ab113958-50μl
50μl
1
$269.90
Ab113958-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
Ab113958-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Mad2L2/REV7 Antibody; WB, IF, ICC; Unconjugated

View related series
Click to view target information: MAD2L2
Accession#:Q9UI95 (1) Gene ID:10459 (1) MAD2L2 (1) REV7 (1)

Basic Description

Product Name Recombinant Mad2L2/REV7 Antibody - Primary antibody, specific to MAD2L2, Rabbit IgG
Synonyms hREV7 | MAD2-like protein 2 | Mitotic arrest deficient 2-like protein 2 | REV7 homolog | Homolog of REV7 S cerevisiae | HREV7 | MAD2 homolog | MAD2 like 2 | MAD2 mitotic arrest deficient like 2 | MAD2B | Mitotic Arrest Deficient 2 L2 | Mitotic arrest defi
Specifications & Purity ExactAb™, Validated, Recombinant, 0.5 mg/mL
Host species Rabbit
Specificity MAD2L2
Immunogen A synthetic peptide derived from human Mad2L2 (AA 178-191)
Positive Control WB: Jurkat, K562, HeLa, MOLT-4 and SK-N-SH cell lysates. ICC/IF: HeLa cells.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Mad2L2/REV7 Antibody, Recombinant, could be used for WB, IF, ICC and so on.

Application:
WB: 1/500-1/1000
ICC/IF: 1/50-1/200

Protein Function：
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Immunogen affinity purified
Shape Liquid
Concentration 0.5 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAD2L2 Tbio Mitotic spindle assembly checkpoint protein MAD2B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Mad2L2/REV7 Antibody (Ab113958) - Western Blot
All lanes: Recombinant Mad2L2/REV7 Antibody (Ab113958) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 24 kDa
Observed band size: 24 kDa
Exposure time: 30.0 s

Recombinant Mad2L2/REV7 Antibody (Ab113958) - IF/ICC
Immunocytochemistry analysis of Mad2L2/REV7 (green) in HeLa using Recombinant Mad2L2/REV7 Antibody (Ab113958), and cells were counterstained with DAPI (blue).

Application

Application Dilution info
WB

1/500-1/1000
IF/ICC

1/50-1/200

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0506096 Certificate of Analysis May 28, 2024 Ab113958
ZJ24F0506097 Certificate of Analysis May 28, 2024 Ab113958

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