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Recombinant LIS1 Antibody - Primary antibody, specific to PAFAH1B1, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Hamster,Human,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab113262
Grouped product items
SKU Size
Availability
 Price Qty
Ab113262-10μl
10μl
2
$69.90
Ab113262-50μl
50μl
1
$199.90
Ab113262-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab113262-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human LIS1 Antibody; WB; Unconjugated

View related series
Click to view target information: PAFAH1B1
Accession#: P43034 (1) Gene ID: 5048 (1) LIS1 (1) PAFAH1B1 (1)

Basic Description

Product Name Recombinant LIS1 Antibody - Primary antibody, specific to PAFAH1B1, Rabbit IgG
Synonyms LIS 1 | LIS 2 | LIS-1 | LIS1 | LIS1_HUMAN | LIS2 | Lissencephaly 1 protein | Lissencephaly-1 protein | MDCR | MDS | PAF acetylhydrolase 45 kDa subunit | PAF AH 45 kDa subunit | PAF AH alpha | PAF-AH 45 kDa subunit | PAF-AH alpha | PAFAH alpha | PAFAH | PA
Specifications & Purity ExactAb™, Validated, Recombinant, 0.4 mg/mL
Host species Rabbit
Specificity PAFAH1B1
Immunogen A synthetic peptide derived from human LIS1 (AA 64-77)
Positive Control WB: HEK293, SK-OV-3 and SK-N-SH cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human LIS1 Antibody, Recombinant, could be used for WB and so on.

Application:
WB: 1/500-1/1000

Protein Function
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Antigen affinity purified
Shape Liquid
Concentration 0.4 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PAFAH1B1 Tbio Platelet-activating factor acetylhydrolase IB subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant LIS1 Antibody (Ab113262) - Western Blot
All lanes: Recombinant LIS1 Antibody (Ab113262) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 47 kDa
Observed band size: 46 kDa
Exposure time: 195.1 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0506091 Certificate of Analysis May 24, 2024 Ab113262
ZJ24F0506090 Certificate of Analysis May 24, 2024 Ab113262

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