TLR2 Mouse mAb

COA

级别和纯度:

见COA

应用:

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: C9
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab131480-10μl	10μl	现货
Ab131480-50μl	50μL	现货
Ab131480-100μl	100μL	期货
Ab131480-1ml	1ml	期货

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点击查看靶蛋白信息: TLR2

Accession#:O60603 (2) Gene ID:7097 (2) TLR2 (2)

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基本信息

产品名称	TLR2 Mouse mAb
别名	Toll样受体单克隆抗体 \| TLR2 小鼠单克隆抗体 \| TLR2 小鼠单抗
英文别名	CD282 antibody \| CD282 antigen antibody \| TIL 4 antibody \| TIL4 antibody \| TLR 2 antibody \| TLR2 antibody \| TLR2_HUMAN antibody \| Toll like receptor 2 antibody \| Toll like receptor 2 precursor antibody \| Toll-like receptor 2 antibody \| Toll/interleukin 1
规格或纯度	无载体, ExactAb™, 已验证, 高性能, 见COA
宿主种属	小鼠(Mouse)
特异性	TLR2
种属反应性	人(Human)
免疫原	Recombinant TLR2 expressed in E.coli (AA 47-245)
阳性对照	WB: Human milk lysate.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	C9
Format	Whole IgG
亚型	Mouse IgG1
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A + Protein G purified
物理外观	Liquid
储存缓冲液	10mM PBS, 50% Glycerol, 0.02% Sodium azide, pH7.4
防腐剂	0.02% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4℃ 短期储存（1-2 周）。-20℃长期保存（24 个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

TLR2 Tchem Toll 类受体 2(Toll-like receptor 2) (0 活性数据)

点击查看靶蛋白信息： TLR2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TLR2 Tchem Toll-like receptor 2 (975 活性数据)

点击查看靶蛋白信息： TLR2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

TLR2 Tchem TLR2/TLR6 (50 活性数据)

点击查看靶蛋白信息： TLR2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: TLR2 Mouse mAb (Ab131480)

TLR2 Mouse mAb (Ab131480) - Western Blot
All lanes: TLR2 Mouse mAb (Ab131480) at 1/1000 dilution
Samples: Lysates at 20 µL per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/10000 dilution

Predicted band size: 90 kDa
Observed band size: 92 kDa
Exposure time: 95.6 s

应用

应用名称	稀释比例
WB	0.01-2 µg/mL

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0202903	分析证书	Ab131480
ZJ24F0202902	分析证书	Ab131480
ZJ24F0202901	分析证书	Ab131480

技术文档和文章

蛋白质印迹的一抗选择指南

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重组抗体单克隆抗体多克隆抗体蛋白质印迹内参抗体一抗选择

Guidelines of Primary Antibodies for Western Blotting

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Western blotting Monoclonal antibodies Recombinant Antibodies Polyclonal Antibodies Primary Antibodies Selection Loading Controls

Guidelines of Primary Antibodies for Western Blotting

Categories: 实验方案（Protocols）

探索主题:

Western blotting Monoclonal antibodies Recombinant Antibodies Polyclonal Antibodies Primary Antibodies Selection Loading Controls

高分子量蛋白质印迹法

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免疫印迹生物缓冲液蛋白质印迹高分子量蛋白大分子蛋白蛋白质电泳 WB抗体

Protocol of Western Blotting For High Molecular Weights

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Western blotting Biological buffer Immunoblotting Protein Electrophoresis High Molecular Weights large molecular proteins WB antibody

Protocol of Western Blotting For High Molecular Weights

Categories: 实验方案（Protocols）

探索主题:

Western blotting Biological buffer Immunoblotting Protein Electrophoresis High Molecular Weights large molecular proteins WB antibody

Protocol of Western Blotting For High Molecular Weights

Categories: 实验方案（Protocols）

探索主题:

Western blotting Biological buffer Immunoblotting Protein Electrophoresis High Molecular Weights large molecular proteins WB antibody

Protocol of Western Blotting For High Molecular Weights

Categories: 实验方案（Protocols）

探索主题:

Western blotting Biological buffer Immunoblotting Protein Electrophoresis High Molecular Weights large molecular proteins WB antibody

引用文献

1. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.. J Immunol, 163 (1): (1-5). [PMID:10384090]
2. Huynh AS, Chung WJ, Cho HI, Moberg VE, Celis E, Morse DL, Vagner J. (2012) Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy.. J Med Chem, 55 (22): (9751-62). [PMID:23098072]
3. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL et al.. (2013) Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.. J Med Chem, 56 (11): (4206-23). [PMID:23656327]
4. Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus Jr R, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB et al.. (2016) The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.. J Med Chem, 59 (10): (4867-80). [PMID:27109867]
5. Bulut Y, Faure E, Thomas L, Equils O, Arditi M. (2001) Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.. J Immunol, 167 (2): (987-94). [PMID:11441107]
6. Morin MD, Wang Y, Jones BT, Mifune Y, Su L, Shi H, Moresco EMY, Zhang H, Beutler B, Boger DL. (2018) Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists.. J Am Chem Soc, 140 (43): (14440-14454). [PMID:30272974]
7. Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B, Zhang H. (2019) Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.. J Med Chem, 62 (6): (2938-2949). [PMID:30829478]
8. Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ, Mehlmann JF, King BW et al.. (2019) Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.. J Med Chem, 62 (14): (6482-6494). [PMID:31265286]
9. Mackman RL, Mish M, Chin G, Perry JK, Appleby T, Aktoudianakis V, Metobo S, Pyun P, Niu C, Daffis S et al.. (2020) Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.. J Med Chem, 63 (18): (10188-10203). [PMID:32407112]
10. Wenyan Wu,Rongti Li,Subbalakshmi S Malladi,Hemamali J Warshakoon,Matthew R Kimbrell,Michael W Amolins,Rehman Ukani,Apurba Datta,Sunil A David. (2010-03-23) Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.. Journal of medicinal chemistry, 53 ((8)): (3198-3213). [PMID:20302301]
11. Chen L, Zhang Y, Sun X, Li H, LeSage G, Javer A, Zhang X, Wei X, Jiang Y, Yin D.. (2009) Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3beta pathway.. Bioorg Med Chem, 17 (13): (4378-4382). [PMID:19477653] [10.1016/j.bmc.2009.05.029]
12. Salunke DB, Shukla NM, Yoo E, Crall BM, Balakrishna R, Malladi SS, David SA.. (2012) Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides.. J Med Chem, 55 (7): (3353-3363). [PMID:22385476] [10.1021/jm3000533]
13. Kokatla HP, Sil D, Malladi SS, Balakrishna R, Hermanson AR, Fox LM, Wang X, Dixit A, David SA.. (2013) Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.. J Med Chem, 56 (17): (6871-6885). [PMID:23899291] [10.1021/jm400694d]
14. Beesu M, Malladi SS, Fox LM, Jones CD, Dixit A, David SA.. (2014) Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.. J Med Chem, 57 (17): (7325-7341). [PMID:25102141] [10.1021/jm500701q]
15. Wang S, Yang J, Li X, Liu Z, Wu Y, Si G, Tao Y, Zhao N, Hu X, Ma Y, Liu G.. (2017) Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo.. J Med Chem, 60 (12): (5162-5192). [PMID:28541685] [10.1021/acs.jmedchem.7b00608]
16. Zhang L, Shi L, Soars SM, Kamps J, Yin H.. (2018) Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties.. J Med Chem, 61 (14): (5881-5899). [PMID:29870245] [10.1021/acs.jmedchem.7b01557]
17. Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin H.. (2020) Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.. J Med Chem, 63 (8): (4117-4132). [PMID:32233366] [10.1021/acs.jmedchem.9b02128]
18. Achek A, Shah M, Seo JY, Kwon HK, Gui X, Shin HJ, Cho EY, Lee BS, Kim DJ, Lee SH, Yoo TH, Kim MS, Choi S.. (2019) Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model.. J Med Chem, 62 (14): (6495-6511). [PMID:31283217] [10.1021/acs.jmedchem.9b00061]
19. Ashhurst AS, McDonald DM, Hanna CC, Stanojevic VA, Britton WJ, Payne RJ.. (2019) Mucosal Vaccination with a Self-Adjuvanted Lipopeptide Is Immunogenic and Protective against Mycobacterium tuberculosis.. J Med Chem, 62 (17): (8080-8089). [PMID:31373811] [10.1021/acs.jmedchem.9b00832]
20. McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Scholliers A, Thoné T, Van Schoubroeck B, De Pooter D, Mostmans W, Khamlichi MD, Embrechts W, Dhuyvetter D, Smyej I, Arnoult E, Demin S, Borghys H, Fanning G, Vlach J, Raboisson P.. (2016) Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.. J Med Chem, 59 (17): (7936-7949). [PMID:27513093] [10.1021/acs.jmedchem.6b00747]
21. Knoepfel T, Nimsgern P, Jacquier S, Bourrel M, Vangrevelinghe E, Glatthar R, Behnke D, Alper PB, Michellys PY, Deane J, Junt T, Zipfel G, Limonta S, Hawtin S, Andre C, Boulay T, Loetscher P, Faller M, Blank J, Feifel R, Betschart C.. (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.. J Med Chem, 63 (15): (8276-8295). [PMID:32786235] [10.1021/acs.jmedchem.0c00130]
22. Federico S,Pozzetti L,Papa A,Carullo G,Gemma S,Butini S,Campiani G,Relitti N. (2020) Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists.. J Med Chem, 63 (22): (13466-13513). [PMID:32845153] [10.1021/acs.jmedchem.0c01049]
23. Rock, F L FL, Hardiman, G G, Timans, J C JC, Kastelein, R A RA and Bazan, J F JF.. (1998) A family of human receptors structurally related to Drosophila Toll.. Proceedings of the National Academy of Sciences of the United States of America, (20): [PMID:9435236]
24. Chaudhary, P M PM and 9 more authors.. (1998) Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.. Blood, (1): [PMID:9596645]
25. Yang, R B RB and 9 more authors.. (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.. Nature, (17): [PMID:9751057]
26. Brightbill, H D HD and 13 more authors.. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.. Science (New York, N.Y.), (30): [PMID:10426995]
27. Aliprantis, A O AO and 8 more authors.. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.. Science (New York, N.Y.), (30): [PMID:10426996]
28. Xu, Y Y and 6 more authors.. (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.. Nature, (2): [PMID:11081518]
29. Kang, T J TJ and Chae, G T GT.. (2001) Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.. FEMS immunology and medical microbiology, [PMID:11476982]
30. Yamamoto, Masahiro M and 6 more authors.. (2002) Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12471095]
31. Bochud, Pierre-Yves PY, Hawn, Thomas R TR and Aderem, Alan A.. (2003) Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:12646604]
32. Weber, Alexander N R AN, Morse, Mary A MA and Gay, Nicholas J NJ.. (2004) Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion.. The Journal of biological chemistry, (13): [PMID:15173186]
33. Bulut, Yonca Y and 6 more authors.. (2005) Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.. The Journal of biological chemistry, (3): [PMID:15809303]
34. Jung, Saet-Byel SB and 11 more authors.. (2006) The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.. Infection and immunity, [PMID:16622205]
35. Triantafilou, Martha M and 6 more authors.. (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.. The Journal of biological chemistry, (13): [PMID:16880211]
36. Khor, Chiea C CC and 33 more authors.. (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.. Nature genetics, [PMID:17322885]
37. Tenaud, Isabelle I, Khammari, Amir A and Dreno, Brigitte B.. (2007) In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.. Experimental dermatology, [PMID:17518990]
38. Jin, Mi Sun MS and 7 more authors.. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.. Cell, (21): [PMID:17889651]
39. Nakajima, Toshiaki T and 6 more authors.. (2008) Natural selection in the TLR-related genes in the course of primate evolution.. Immunogenetics, [PMID:18810425]
40. Strapagiel, Dominik D and 7 more authors.. (2008) Monocyte response receptors in BCG driven delayed type hypersensitivity to tuberculin.. Folia histochemica et cytobiologica, [PMID:19056540]
41. Drage, Michael G and 7 more authors.. (2009) TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.. Cellular immunology, [PMID:19362712]
42. Georgel, Philippe P, Macquin, Cécile C and Bahram, Seiamak S.. (2009) The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.. PloS one, (17): [PMID:19924287]
43. Chambers, Mark A MA and 6 more authors.. (2010) Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9.. Biochemical and biophysical research communications, (24): [PMID:20800577]
44. Lancioni, Christina L CL and 11 more authors.. (2011) Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.. Infection and immunity, [PMID:21078852]
45. Ben-Ali, Meriem M and 7 more authors.. (2011) Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.. Human mutation, [PMID:21618349]
46. Boada-Romero, Emilio E and 5 more authors.. (2013) TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.. The EMBO journal, (20): [PMID:23376921]
47. Stack, Julianne and 7 more authors.. (2014) TRAM is required for TLR2 endosomal signaling to type I IFN induction.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:25385819]
48. and Leyden, James J.. (2016) Recent advances in the use of adapalene 0.1%/benzoyl peroxide 2.5% to treat patients with moderate to severe acne.. The Journal of dermatological treatment, [PMID:26947815]
49. McKelvey, Alison C AC and 9 more authors.. (2016) RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.. eLife, (2): [PMID:27805901]
50. Biyikli, Oguz Oben OO and 5 more authors.. (2016) Role of Toll-Like Receptors in Tuberculosis Infection.. Jundishapur journal of microbiology, [PMID:27942355]

溶液计算器

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计算溶液所需的质量、体积或浓度。

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体积

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g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

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体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

TLR2 Mouse mAb

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器