CD105 Mouse mAb

COA

级别和纯度:

无载体

已验证

ExactAb™

1.0 mg/mL

应用:

ELISA
IF/ICC
IHC
WB

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: 3A9
偶联: Unconjugated

有货

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库存信息

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关闭

货号 (SKU)	包装规格	是否现货
Ab093671-10μl	10μl	现货
Ab093671-50μl	50μL	现货
Ab093671-100μl	100μL	现货
Ab093671-1ml	1ml	期货

查看相关系列

点击查看靶蛋白信息: ENG

Accession#:P17813 (9) CD105 (5) ENG (9) Gene ID:2022 (9)

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基本信息

产品名称	CD105 Mouse mAb
别名	CD105小鼠单抗 \| CD105小鼠单克隆抗体 \| CD105小鼠单抗
英文别名	AI528660 antibody \| AI662476 antibody \| CD 105 antibody \| CD105 antibody \| CD105 antigen antibody \| EGLN_HUMAN antibody \| END antibody \| Endoglin antibody \| Eng antibody \| FLJ41744 antibody \| HHT1 antibody \| ORW antibody \| ORW1 antibody \| Osler Rendu Webe
规格或纯度	ExactAb™, Validated, Carrier Free, 1.0 mg/mL
宿主种属	小鼠(Mouse)
特异性	CD105
种属反应性	人(Human)
免疫原	Purified recombinant fragment of Human CD105, expressed in E. coli
阳性对照	WB: HUVEC cell lysate. ICC/IF: Hep G2 cells. Flow: Hep G2 cells. IHC: Human kidney cancer and stomach cancer tissues.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	3A9
Format	Whole IgG
亚型	IgG1
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein G purified
物理外观	Liquid
储存缓冲液	Purified antibody in PBS with 0.05% sodium azide
防腐剂	0.05% sodium azide
浓度	1.0 mg/mL
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	储存：4℃; -20℃ 长期保存。避免反复冻融循环。
分子类型	抗体

关联靶点（人）

ENG Tbio 内皮糖蛋白(Endoglin) (0 活性数据)

点击查看靶蛋白信息： ENG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: CD105 Mouse mAb (Ab093671)

CD105 Mouse mAb (Ab093671) - Western Blot
All lanes: CD105 Mouse mAb (Ab093671) at 1/1000 dilution
Samples: Lysates at 10 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/30000 dilution

Predicted band size: 71 kDa
Observed band size: 93 kDa

ICC/IF: CD105 Mouse mAb (Ab093671)

CD105 Mouse mAb (Ab093671) - ICC/IF
Immunofluorescence analysis of Hep G2 cells using CD105 Mouse mAb (Ab093671) at a 1/200 dilution (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with AF555 phalloidin.

Flow Cytometry: CD105 Mouse mAb (Ab093671)

CD105 Mouse mAb (Ab093671) - Flow Cytometry
Flow cytometric analysis of Hep G2 cells using CD105 Mouse mAb (Ab093671)
at a dilution of 1/200 (green) and negative control (purple).

IHC: CD105 Mouse mAb (Ab093671)

CD105 Mouse mAb (Ab093671) - IHC
Immunohistochemical analysis of paraffin-embedded Human kidney cancer tissues using CD105 Mouse mAb (Ab093671) at a dilution of 1/200 with DAB staining.

IHC: CD105 Mouse mAb (Ab093671)

CD105 Mouse mAb (Ab093671) - IHC
Immunohistochemical analysis of paraffin-embedded Human stomach cancer tissues using CD105 Mouse mAb (Ab093671) at a dilution of 1/200 with DAB staining.

应用

应用名称	稀释比例
WB	1/500-1/2000
IHC	1/200-1/1000
ELISA	1/10000
IF/ICC	1/200 - 1/1000

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C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0911259	分析证书	Ab093671
ZJ23F0800758	分析证书	Ab093671
ZJ23F0800759	分析证书	Ab093671

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引用文献

1. Cheifetz, S S and 6 more authors.. (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.. The Journal of biological chemistry, (25): [PMID:1326540]
2. Gougos, A A and Letarte, M M.. (1990) Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.. The Journal of biological chemistry, (25): [PMID:1692830]
3. McAllister, K A KA and 9 more authors.. (1994) Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.. Nature genetics, [PMID:7894484]
4. Bellón, T T and 9 more authors.. (1993) Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions.. European journal of immunology, [PMID:8370410]
5. Yamaguchi, H H, Azuma, H H, Shigekiyo, T T, Inoue, H H and Saito, S S.. (1997) A novel missense mutation in the endoglin gene in hereditary hemorrhagic telangiectasia.. Thrombosis and haemostasis, [PMID:9157574]
6. Shovlin, C L CL, Hughes, J M JM, Scott, J J, Seidman, C E CE and Seidman, J G JG.. (1997) Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia.. American journal of human genetics, [PMID:9245986]
7. Gallione, C J CJ and 18 more authors.. (1998) Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles.. Human mutation, [PMID:9554745]
8. Pece-Barbara, N N, Cymerman, U U, Vera, S S, Marchuk, D A DA and Letarte, M M.. (1999) Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1.. Human molecular genetics, [PMID:10545596]
9. Cymerman, U U and 6 more authors.. (2000) Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin.. Pediatric research, [PMID:10625079]
10. Gallione, C J CJ and 6 more authors.. (2000) Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect.. Human genetics, [PMID:10982033]
11. Lesca, Gaëtan G and 15 more authors.. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France.. Human mutation, [PMID:15024723]
12. Humphray, S J SJ and 147 more authors.. (2004) DNA sequence and analysis of human chromosome 9.. Nature, (27): [PMID:15164053]
13. Kuehl, Heidi K A HK and 6 more authors.. (2005) Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations.. Human mutation, [PMID:15712270]
14. Argyriou, Loukas L and 6 more authors.. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia.. International journal of molecular medicine, [PMID:16525724]
15. Bossler, Aaron D AD, Richards, Jennifer J, George, Cicily C, Godmilow, Lynn L and Ganguly, Arupa A.. (2006) Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype.. Human mutation, [PMID:16752392]
16. Meng, Qingjun Q and 10 more authors.. (2006) Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.. The Journal of biological chemistry, (1): [PMID:16982625]
17. Lee, Nam Y NY and Blobe, Gerard C GC.. (2007) The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.. The Journal of biological chemistry, (20): [PMID:17540773]
18. Richards-Yutz, Jennifer J, Grant, Kathleen K, Chao, Elizabeth C EC, Walther, Susan E SE and Ganguly, Arupa A.. (2010) Update on molecular diagnosis of hereditary hemorrhagic telangiectasia.. Human genetics, [PMID:20414677]
19. Castonguay, Roselyne R and 11 more authors.. (2011) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.. The Journal of biological chemistry, (26): [PMID:21737454]
20. Alt, Aaron A and 8 more authors.. (2012) Structural and functional insights into endoglin ligand recognition and binding.. PloS one, [PMID:22347366]
21. Nolan-Stevaux, Olivier O and 6 more authors.. (2012) Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies.. PloS one, [PMID:23300529]
22. Saito, Takako T and 7 more authors.. (2017) Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.. Cell reports, (30): [PMID:28564608]

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体积（添加到小瓶中）

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所需的复溶浓度

CD105 Mouse mAb

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器