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Recombinant Rad50 Antibody - Primary antibody, specific to RAD50, Rabbit IgG

COA COA
    Application:
  • IHC
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab124364
Grouped product items
SKU Size
Availability
 Price Qty
Ab124364-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab124364-50μl
50μl
2
$207.90
Ab124364-100μl
100μl
1
$297.90
Ab124364-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,307.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Rad50 Antibody; WB, IHC; Unconjugated

View related series
Click to view target information: RAD50
Accession#:Q92878 (1) Gene ID:10111 (1) RAD50 (1)

Basic Description

Product Name Recombinant Rad50 Antibody - Primary antibody, specific to RAD50, Rabbit IgG
Synonyms DNA repair protein RAD50 antibody | HRAD50 antibody | HsRAD50 antibody | Mrell antibody | NBSLD antibody | Rad 50 antibody | RAD50 2antibody | rad50 antibody | RAD50 homolog (S cerevisiae) antibody | RAD50 homolog antibody | RAD50 PEN antibody | RAD50, S.
Specifications & Purity ExactAb™, Validated, Recombinant, 0.6 mg/mL
Host species Rabbit
Specificity RAD50
Immunogen Recombinant protein of human Rad50 (AA 1-425).
Positive Control WB: MOLT-4, Jurkat and K562 cell lysates. IHC: Human Cholangiocarcinoma.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Rad50 Antibody, Recombinant, could be used for WB, IHC and so on.
Application:
· WB: 1/500-1/1000
· IHC: 1/50-1/100
Protein Function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kD
Purification Method Antigen affinity purified
Shape Liquid
Concentration 0.6 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

RAD50 Tbio DNA repair protein RAD50 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant Rad50 Antibody (Ab124364) - Western Blot
All lanes: Recombinant Rad50 Antibody (Ab124364) at 1/1500 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution

Predicted band size: 153 kDa
Observed band size: 151 kDa
Exposure time: 5.0 s

Recombinant Rad50 Antibody (Ab124364) - IHC
Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma tissue using Recombinant Rad50 Antibody (Ab124364). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Application

Application Dilution info
WB

1/500-1/1000
IHC

1/50 - 1/100

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F0800953 Certificate of Analysis Sep 04, 2023 Ab124364
ZJ23F0800954 Certificate of Analysis Sep 04, 2023 Ab124364

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