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Recombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG

Grade & Purity:

0.24 mg/mL

Application:

Host species: Rabbit
Reactive species: Human
Isotype: Rabbit IgG
Clone Number: MyR1-LEF1
Conjugation: Unconjugated

In stock

Item Number

Ab112964

Grouped product items
SKU	Size	Availability	Price
Ab112964-10μl	10μl	5	$49.90
Ab112964-50μl	50μl	2	$159.90
Ab112964-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$229.90
Ab112964-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,199.90

Recombinant (MyR1-LEF1); Rabbit anti Human LEF1 Antibody; IHC; Unconjugated

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Click to view target information: LEF1

Accession#:Q9UJU2 (2) Gene ID:51176 (2) LEF1 (2)

Basic Description

Product Name	Recombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG
Synonyms	DKFZp586H0919 antibody \| FLJ46390 antibody \| LEF 1 antibody \| LEF-1 antibody \| Lef1 antibody \| LEF1_HUMAN antibody \| Lymphoid enhancer binding factor 1 antibody \| Lymphoid enhancer-binding factor 1 antibody \| T cell specific transcription factor 1 alpha a
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.24 mg/mL
Host species	Rabbit
Specificity	LEF1
Positive Control	IHC: Human tonsil tissue.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human LEF1 Antibody, Recombinant (MyR1-LEF1), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Shape	Liquid
Concentration	0.24 mg/mL
Storage Temp	Store at 2-8°C,Do not freeze
Shipped In	Wet ice
Stability And Storage	Store at 2-8°C long term (36 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

LEF1 Tchem Lymphoid enhancer-binding factor 1 (0 Activities)

Discover Target: LEF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Images

IHC: Recombinant LEF1 Antibody (Ab112964) 

Recombinant LEF1 Antibody (Ab112964) - IHC
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling LEF1 with Recombinant LEF1 Antibody (Ab112964) at 1/200 dilution. The section was incubated with Ab112964 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.

Application

Application	Dilution info
IHC	1/100 - 1/200

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505264	Certificate of Analysis	May 09, 2024	Ab112964
ZJ24F0505263	Certificate of Analysis	May 09, 2024	Ab112964

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Recombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG

Basic Description

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Application

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews

Recombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG

Basic Description

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Application

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Related Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews