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Nimotuzumab (anti-EGFR) - Primary antibody, specific to EGFR, >95%, high purity, Human IgG1, INHIBITOR of Epidermal growth factor receptor erbB1 inhibitor, INHIBITOR of Epidermal growth factor receptor erbB1 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175612
Grouped product items
SKU Size
Availability
 Price Qty
Ab175612-100μg
100μg
10
$99.90
Ab175612-1mg
1mg
4
$479.90
Ab175612-5mg
5mg
1
$1,669.90
Ab175612-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,669.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: EGFR
Accession#:P00533 (37) EGFR (254) Gene ID:1956 (38) Receptor Tyrosine Kinase (1260)

Basic Description

Product Name Nimotuzumab (anti-EGFR) - Primary antibody, specific to EGFR, >95%, high purity, Human IgG1, INHIBITOR of Epidermal growth factor receptor erbB1 inhibitor
Synonyms Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody | Cell proliferation inducing protein 61 antibody | EGF R antibody | EGFR antibody | EGFR_HUMAN antibody | Epidermal growth factor recepto
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity EGFR
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Epidermal growth factor receptor erbB1 inhibitor
Product Description

Nimotuzumab (anti-EGFR) is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab (anti-EGFR) is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab (anti-EGFR), a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC)[1][2].

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.8 kDa (Light Chain) & 51.6kDa (Heavy Chain), under reducing conditions; 189.1 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 780758-10-3

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin EGFR/PPP1CA (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin VHL/EGFR (323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Nimotuzumab (anti-EGFR) (Ab175612) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Nimotuzumab (anti-EGFR) (Ab175612). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Nimotuzumab (anti-EGFR) (Ab175612) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling EGFR (red) with Nimotuzumab (anti-EGFR) (Ab175612). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Nimotuzumab (anti-EGFR) (Ab175612) - SEC
The purity of Nimotuzumab (anti-EGFR) (Ab175612) is more than 95% verified by HPLC.

Nimotuzumab (anti-EGFR) (Ab175612) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0403995 Certificate of Analysis Apr 01, 2024 Ab175612
ZJ24F0403994 Certificate of Analysis Apr 01, 2024 Ab175612
ZJ24F0403993 Certificate of Analysis Apr 01, 2024 Ab175612

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