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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab183436-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$69.90
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Ab183436-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$349.90
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Ab183436-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$669.90
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Ab183436-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,069.90
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Zalutumumab (anti-EGFR) - Primary antibody, specific to EGFR, Human IgG1, ANTAGONIST of Epidermal growth factor receptor erbB1 antagonist |
|---|---|
| Synonyms | Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody | Cell proliferation inducing protein 61 antibody | EGF R antibody | EGFR antibody | EGFR_HUMAN antibody | Epidermal growth factor recepto |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, |
| Host species | Human |
| Specificity | EGFR |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of Epidermal growth factor receptor erbB1 antagonist |
| Product Description |
Zalutumumab (anti-EGFR) is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab (anti-EGFR) binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab (anti-EGFR) binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab (anti-EGFR) can be used for the research of cancer. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 146.52 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 667901-13-5 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Zalutumumab (anti-EGFR) (Ab183436) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Zalutumumab (anti-EGFR) (Ab183436) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Zalutumumab (anti-EGFR) (Ab183436) - SEC
The purity of Zalutumumab (anti-EGFR) (Ab183436) is more than 95% verified by HPLC.
Zalutumumab (anti-EGFR) (Ab183436) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Zalutumumab (anti-EGFR) (Ab183436) with the EC50 of 30.92 ng/mL.
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