Muromonab (anti-CD3)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG2a
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab170491-100μg	100μg	现货
Ab170491-1mg	1mg	现货
Ab170491-5mg	5mg	现货
Ab170491-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD3E

Accession#:P07766 (43) CD3 (46) CD3E (62) Gene ID:916 (41)

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基本信息

产品名称	Muromonab (anti-CD3)
别名	莫罗单抗 \| CD3抗体 \| CD3单克隆抗体 \| CD3药靶抗体 \| CD3E抗体 \| CD3E单克隆抗体 \| CD3E药靶抗体
英文别名	CD_antigen: CD3e \| CD3 antigen, delta subunit \| CD3 \| CD3d antigen \| CD3d antigen, delta polypeptide (TiT3 complex) \| CD3d molecule, delta (CD3-TCR complex) \| CD3-DELTA \| CD3e antigen \| CD3e antigen, epsilon polypeptide (TiT3 complex) \| CD3e molecule, eps
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	The CD3 complex mediates signal transduction.
宿主种属	小鼠(Mouse)
特异性	CD3
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human)
偶联	Unconjugated

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Mouse IgG2a
轻链亚型	kappa
SDS-PAGE	146.34 kDa
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	长期储存-80℃（24个月）；收货后建议分装，避免反复冻融。
CAS编号和信息	140608-64-6
分子类型	抗体

关联靶点（人）

CD3E Tclin 细胞表面糖蛋白 CD3 ε 链(T-cell surface glycoprotein CD3 epsilon chain) (0 活性数据)

点击查看靶蛋白信息： CD3E

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 活性数据)

点击查看靶蛋白信息： CD3E

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Muromonab (anti-CD3) (Ab170491)

Muromonab (anti-CD3) (Ab170491) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3 with Muromonab (anti-CD3) (Ab170491) (right panel) conjugated with biotin compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Muromonab (anti-CD3) (Ab170491)

Muromonab (anti-CD3) (Ab170491) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3 (red) with Muromonab (anti-CD3) (Ab170491) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Muromonab (anti-CD3) (Ab170491)

Muromonab (anti-CD3) (Ab170491) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Muromonab (anti-CD3) (Ab170491). Goat Anti-Human IgG (FITC) (Ab175834) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Muromonab (anti-CD3) (Ab170491)

Muromonab (anti-CD3) (Ab170491) - SEC
The purity of Muromonab (anti-CD3) (Ab170491) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001371	分析证书	Ab170491
ZJ23F1001372	分析证书	Ab170491
ZJ24F0708072	分析证书	Ab170491

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引用文献

1. Linke R, Klein A, Seimetz D. (2010) Catumaxomab: clinical development and future directions.. MAbs, 2 (2): (129-36). [PMID:20190561]
2. Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B. (1993) Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.. Nat Genet, 3 (1): (77-81). [PMID:8490660]
3. de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F. (2004) Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.. J Clin Invest, 114 (10): (1512-7). [PMID:15546002]
4. Mathur D, Root AR, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, Kearney JC, Lucas J, Guffroy M, Golas J et al.. (2020) A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.. Clin Cancer Res, 26 (9): (2188-2202). [PMID:31996389]
5. Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar S, Cortés JR, Perona A, Abia D, Blanco S et al.. (2016) First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.. Sci Transl Med, 8 (370): (370ra184). [PMID:28003549]
6. Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E et al.. (2015) Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.. Sci Transl Med, 7 (287): (287ra70). [PMID:25972002]
7. Lanier, L L LL, Chang, C C, Spits, H H and Phillips, J H JH.. (1992) Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:1387664]
8. Barber, E K EK, Dasgupta, J D JD, Schlossman, S F SF, Trevillyan, J M JM and Rudd, C E CE.. (1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2470098]
9. Gold, D P DP and 6 more authors.. (1986) Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.. Nature, [PMID:3012357]
10. Salomon, Arthur R AR and 10 more authors.. (2003) Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.. Proceedings of the National Academy of Sciences of the United States of America, (21): [PMID:12522270]
11. Brill, Laurence M LM and 5 more authors.. (2004) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.. Analytical chemistry, (15): [PMID:15144186]
12. Gimferrer, Idoia I and 8 more authors.. (2004) Relevance of CD6-mediated interactions in T cell activation and proliferation.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15294938]
13. Arnett, Kelly L KL, Harrison, Stephen C SC and Wiley, Don C DC.. (2004) Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.. Proceedings of the National Academy of Sciences of the United States of America, (16): [PMID:15534202]
14. Gaglia, Jason and Kissler, Stephan.. (2019) Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance.. Biochemistry, (8): [PMID:31523950]
15. Clevers, H C HC, Dunlap, S S, Wileman, T E TE and Terhorst, C C.. (1988) Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3267235]
16. Fütterer, K K, Wong, J J, Grucza, R A RA, Chan, A C AC and Waksman, G G.. (1998) Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.. Journal of molecular biology, (21): [PMID:9698567]
17. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]

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Muromonab (anti-CD3)

库存信息

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库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器