Recombinant CD11b Antibody

COA

级别和纯度:

≥95%(SDS-PAGE)
见COA

应用:

ELISA
Flow Cytometry

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: P56E55
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab219625-10μg	10μg	现货
Ab219625-50μg	50μg	现货
Ab219625-100μg	100μg	现货
Ab219625-1mg	1mg	现货

查看相关系列

点击查看靶蛋白信息: ITGAM

Accession#:P11215 (27) CD11B (23) Gene ID:3684 (27) Itgam (28)

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基本信息

产品名称	Recombinant CD11b Antibody
别名	CD11抗原样家族成员B \| 整合素alpha M \| CD11b抗体 \| ITGAM抗体 \| Anti-CD11b抗体 \| 小鼠抗人CD11b抗体
英文别名	antigen CD11b (p170) antibody \| Antigen CD11b p170 antibody \| CD11 antigen like family member B antibody \| CD11 antigen-like family member B antibody \| CD11b antibody \| CD11b/CD18 antibody \| CD49d antibody \| Cell surface glycoprotein MAC-1 subunit alpha a
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity)
宿主种属	小鼠(Mouse)
特异性	Human CD11b
种属反应性	人(Human)
免疫原	Human monocytes
阳性对照	Flow Cytometry: Human peripheral blood monocytes
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 8.0
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。
分子类型	抗体

关联靶点（人）

ITGAM Tbio 整合素α-M(Integrin alpha-M) (0 活性数据)

点击查看靶蛋白信息： ITGAM

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant CD11b Antibody (Ab219625)

Recombinant CD11b Antibody (Ab219625) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD11b with Recombinant CD11b Antibody (Ab219625) (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Ab170221) (left panel) and detected with Alexa Fluor 488 - conjugated affinipure goat anti - Mouse IgG.

Flow Cytometry: Recombinant CD11b Antibody (Ab219625)

Recombinant CD11b Antibody (Ab219625) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD11b (red) with Recombinant CD11b Antibody (Ab219625) at 0.2 μg/mL for 1 hour at 4°C and detected with Alexa Fluor 488 - conjugated affinipure goat anti-Mouse IgG. Blue - Mouse IgG Isotype Control Antibody (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.