TXNDC/TMX Mouse mAb

COA

级别和纯度:

见COA

应用:

IF/ICC
IHC
WB

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human), 猴(Monkey)
亚型: Mouse IgG1
克隆号: OTI3H5
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab133078-10μl	10μl	期货
Ab133078-50μl	50μL	期货
Ab133078-100μl	100μL	期货
Ab133078-1ml	1ml	期货

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点击查看靶蛋白信息: TMX1

Accession#: Q9H3N1 (1) Gene ID: 81542 (1) TMX (1) TMX1 (1) TXNDC (1) TXNDC1 (1)

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基本信息

产品名称	TXNDC/TMX Mouse mAb
别名	TXNDC/TMX抗体 \| TXNDC/TMX单克隆抗体 \| TXNDC抗体 \| 硫氧还蛋白域蛋白1抗体 \| TMX单克隆抗体 \| TXNDC单克隆抗体 \| TMX抗体
英文别名	PDIA11 antibody \| Protein disulfide isomerase family A \| Thioredoxin domain containing 1 antibody \| Thioredoxin domain containing antibody \| Thioredoxin domain-containing protein 1 antibody \| Thioredoxin-related transmembrane protein 1 antibody \| TMX anti
规格或纯度	见COA
生化机理	Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum-mitochondria Ca2+ flux (PubMed:27502484).
宿主种属	小鼠(Mouse)
特异性	TXNDC/TMX
种属反应性	人(Human),猴(Monkey)
免疫原	Recombinant full length protein of human TXNDC/TMX produced in HEK293T cell.
阳性对照	WB: HEK293T transfected with pCMV6-ENTRY TMX1 cDNA for 48 hrs; HepG2, HeLa, A549, COS7, Jurkat, MDCK, MCF7 lysates. IHC: Human ovary adenocarcinoma, prostate carcinoma tissues. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY TMX1.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
Format	Whole IgG
SDS-PAGE	150 kDa
纯化方法	Protein G purified
物理外观	Liquid
储存缓冲液	10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂	0.02% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
分子类型	抗体