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| SKU | Size | Availability |
Price | Qty |
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Ab175651-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$49.90
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Ab175651-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$249.90
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Ab175651-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$619.90
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Ab175651-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$989.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Satralizumab (anti-IL-6Ra) - Primary antibody, specific to IL6R, Human IgG2, Antibody of Interleukin-6 receptor |
|---|---|
| Synonyms | Enspryng,RG-6168 | RG6168 | SA-237 | SA237 | sapelizumab (deprecated INN) | satralizumab-mwge |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL6R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | Antibody of Interleukin-6 receptor |
| Product Description |
Satralizumab (anti-IL-6RA), a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab (anti-IL-6RA) prevents dTAA formation and progression in rattus norvegicus. Satralizumab (anti-IL-6RA) can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research. |
| Isotype | Human IgG2 |
|---|---|
| Light Chain Type | kappa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1535963-91-7 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Satralizumab (anti-IL-6Ra) (Ab175651) - ELISA
Immobilized Recombinant Human IL-6R alpha protein at 1.0 μg/mL can bind Satralizumab (anti-IL-6Ra) (Ab175651) with the EC₅₀ of 88.71 ng/mL.
Satralizumab (anti-IL-6Ra) (Ab175651) - SEC
The purity of Satralizumab (anti-IL-6Ra) (Ab175651) is more than 95% verified by HPLC.
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