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Satralizumab (anti-IL-6Ra) - Primary antibody, specific to IL6R, Human IgG2, Antibody of Interleukin-6 receptor, Antibody of Interleukin-6 receptor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab175651
Grouped product items
SKU Size
Availability
Price Qty
Ab175651-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
Ab175651-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
Ab175651-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$619.90
Ab175651-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$989.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Satralizumab (anti-IL-6Ra) - Primary antibody, specific to IL6R, Human IgG2, Antibody of Interleukin-6 receptor
Synonyms Enspryng,RG-6168 | RG6168 | SA-237 | SA237 | sapelizumab (deprecated INN) | satralizumab-mwge
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL6R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of Interleukin-6 receptor
Product Description

Satralizumab (anti-IL-6RA), a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab (anti-IL-6RA) prevents dTAA formation and progression in rattus norvegicus. Satralizumab (anti-IL-6RA) can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Product Properties

Isotype Human IgG2
Light Chain Type kappa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS 1535963-91-7

Associated Targets(Human)

IL6R Tclin Interleukin-6 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL6ST Tclin Interleukin-6 receptor subunit beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL6R Tclin Interleukin-6 receptor alpha subunit (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL6ST Tclin Interleukin-6 receptor subunit beta (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL6R Tclin IL6Ralpha/GP130 (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Satralizumab (anti-IL-6Ra) (Ab175651) - ELISA
Immobilized Recombinant Human IL-6R alpha protein at 1.0 μg/mL can bind Satralizumab (anti-IL-6Ra) (Ab175651) with the EC₅₀ of 88.71 ng/mL.

Satralizumab (anti-IL-6Ra) (Ab175651) - SEC
The purity of Satralizumab (anti-IL-6Ra) (Ab175651) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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