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Vobarilizumab (anti-IL-6Ra) - Primary antibody, specific to IL6R, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor, Antibody of Interleukin-6 receptor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175700
Grouped product items
SKU Size
Availability
Price Qty
Ab175700-100μg
100μg
10
$79.90
Ab175700-1mg
1mg
4
$399.90
Ab175700-5mg
5mg
1
$1,279.90
Ab175700-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Vobarilizumab (anti-IL-6Ra) - Primary antibody, specific to IL6R, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor
Synonyms CD 126 antibody | CD126 antibody | CD126 antigen antibody | gp80 antibody | IL 6R 1 antibody | IL 6R alpha antibody | IL 6R antibody | IL-6 receptor alpha chain antibody | IL-6 receptor subunit alpha antibody | IL-6R 1 antibody | IL-6R subunit alpha antib
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL6R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of Interleukin-6 receptor
Product Description

Vobarilizumab (anti-IL-6Ra) is an anti-IL-6R monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab (anti-IL-6Ra) consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab (anti-IL-6Ra) can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis.

Product Properties

Isotype Human IgG1
SDS-PAGE 78.2 kDa
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1628814-88-9

Associated Targets(Human)

IL6R Tclin Interleukin-6 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL6ST Tclin Interleukin-6 receptor subunit beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL6R Tclin Interleukin-6 receptor alpha subunit (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL6ST Tclin Interleukin-6 receptor subunit beta (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL6R Tclin IL6Ralpha/GP130 (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Vobarilizumab (anti-IL-6Ra) (Ab175700) - ELISA
Immobilized human IL-6R-ECD-chis at 2.0 μg/mL can Vobarilizumab (anti-IL-6Ra) (Ab175700) with the EC₅₀ of 13.89 ng/mL.



Vobarilizumab (anti-IL-6Ra) (Ab175700) - SEC
The purity of Vobarilizumab (anti-IL-6Ra) (Ab175700) is more than 95% verified by HPLC.

Vobarilizumab (anti-IL-6Ra) (Ab175700) - ELISA
Immobilized Recombinant Human IL-6R alpha Protein (rp181252) at 1.0 μg/mL can bind Vobarilizumab (anti-IL-6Ra) (Ab175700) with the EC50 of 67.99 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404187 Certificate of Analysis Apr 07, 2024 Ab175700
ZJ24F0404186 Certificate of Analysis Apr 07, 2024 Ab175700
ZJ24F0404185 Certificate of Analysis Apr 07, 2024 Ab175700

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