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Sarilumab (anti-IL-6Rα) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL6R, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor; α subunit, Antibody of Interleukin-6 receptor; α subunit

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
S412003
Grouped product items
SKU Size
Availability
 Price Qty
S412003-100μg
100μg
10
$39.90
S412003-1mg
1mg
4
$159.90
S412003-5mg
5mg
1
$664.90
S412003-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,196.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: IL6R
Accession#:P08887 (9) Gene ID:3570 (9) IL6R (10) Interleukin-6 receptor，α subunit Antibody (1)

Basic Description

Product Name Sarilumab (anti-IL-6Rα) - Primary antibody, for Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL6R, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor; α subunit
Synonyms gp80 | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R subunit alpha | IL-6RA | IL-6R-alpha | Membrane glycoprotein 80
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL6R
Application Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of Interleukin-6 receptor; α subunit
Product Description

Sarilumab is a human immunoglobulin G1 monoclonal antibody. Sarilumab is an antagonist of the interleukin-6 IL-6 receptor. Sarilumab has a high affinity for the IL-6 receptor and inhibits both cis-and trans-signaling of IL-6, reducing inflammation. Sarilumab can be used in rheumatoid arthritis studies.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.0 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 186.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1189541-98-7

Associated Targets(Human)

IL6R Tclin Interleukin-6 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL6R Tclin Interleukin-6 receptor alpha subunit (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Sarilumab (anti-IL-6Rα) (S412003) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling IL-6Rα (red) with Sarilumab (anti-IL-6Rα) (S412003). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Sarilumab (anti-IL-6Rα) (S412003) - SEC
The purity of Sarilumab (anti-IL-6Rα) (S412003) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0102631 Certificate of Analysis Jan 26, 2024 S412003
ZJ24F0102632 Certificate of Analysis Jan 26, 2024 S412003
ZJ24F0102633 Certificate of Analysis Jan 26, 2024 S412003

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