Grouped product items

SKU

Size

Availability

Price

Qty

T412004-100μg

100μg

$39.90

T412004-1mg

1mg

$159.90

T412004-5mg

5mg

$664.90

T412004-10mg

10mg

Available within 8-12 weeks(?)

$1,196.90

Basic Description

Product Name	Tocilizumab (anti-IL-6R) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL-6Ra/CD126, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor
Synonyms	Q369O8926L \| CHEBI:27881 \| CU-01000001503-3 \| HMS1792H15 \| NSC133100 \| BPBio1_000479 \| NCGC00344093-09 \| RESVERATROL (MART.) \| MLS000069735 \| MLS001076538 \| Stilbene, 2f \| (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol \| MLS002222231 \| TaxusChinensisi
Specifications & Purity	Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species	Human
Specificity	IL-6Ra/CD126
Application	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of Interleukin-6 receptor
Product Description	Tocilizumab is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab can be used for the treatment of rheumatoid arthritis. It is remarkablely effective for the study of severe COVID-19 (coronavirus disease). Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Stilbenes

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Stilbenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Stilbenes
Alternative Parents	Styrenes Resorcinols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Stilbene - Styrene - Resorcinol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors	Diphenyl ethers, biphenyls, dibenzyls and stilbenes
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	26.6 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 174.3 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Source	CHO supernatant
Shape	Liquid
Concentration	See COA
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS	375823-41-9

Associated Targets(Human)

IL6R Tclin Interleukin-6 receptor subunit alpha (0 Activities)

Discover Target: IL6R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL6ST Tclin Interleukin-6 receptor subunit beta (0 Activities)

Discover Target: IL6ST

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL6R Tclin Interleukin-6 receptor alpha subunit (0 Activities)

Discover Target: IL6R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IL6ST Tclin Interleukin-6 receptor subunit beta (58 Activities)

Discover Target: IL6ST

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IL6R Tclin IL6Ralpha/GP130 (4 Activities)

Discover Target: IL6R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Images

ELISA: Tocilizumab (anti-IL-6R) (T412004)

Tocilizumab (anti-IL-6R) (T412004) - ELISA
Immobilized Recombinant Human IL-6R Protein at 2 μg/mL can bind Tocilizumab (anti-IL-6R) (T412004) with the EC₅₀ of 5.8 ng/mL.

SEC: Tocilizumab (anti-IL-6R) (T412004)

Tocilizumab (anti-IL-6R) (T412004) - SEC
The purity of Tocilizumab (anti-IL-6R) (T412004) is more than 95% verified by HPLC.

ELISA: Tocilizumab (anti-IL-6R) (T412004)

Tocilizumab (anti-IL-6R) (T412004) - ELISA
Immobilized Recombinant Human IL-6R alpha Protein (rp181252) at 1.0 μg/mL can bind Tocilizumab (anti-IL-6R) (T412004) with the EC50 of 21.05 ng/mL.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404271	Certificate of Analysis	Apr 10, 2024	T412004
ZJ24F0404272	Certificate of Analysis	Apr 10, 2024	T412004
ZJ24F0404270	Certificate of Analysis	Apr 10, 2024	T412004

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Tocilizumab (anti-IL-6R) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL-6Ra/CD126, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor, Antibody of Interleukin-6 receptor

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews

Tocilizumab (anti-IL-6R) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL-6Ra/CD126, >95%, high purity, Human IgG1, Antibody of Interleukin-6 receptor, Antibody of Interleukin-6 receptor

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Related Products

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews