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Recombinant RAGE Antibody - Primary antibody, specific to RAGE, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab124452
Grouped product items
SKU Size
Availability
 Price Qty
Ab124452-10μl
10μl
2
$59.90
Ab124452-50μl
50μl
1
$169.90
Ab124452-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$269.90
Ab124452-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,099.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human RAGE Antibody; WB; Unconjugated

View related series
Click to view target information: AGER
Accession#:Q15109 (4) AGER (4) Gene ID:177 (4) RAGE (4)

Basic Description

Product Name Recombinant RAGE Antibody - Primary antibody, specific to RAGE, Rabbit IgG
Synonyms Ager antibody | DAMA 358M23.4 antibody | MGC2235 antibody | MGC22357 antibody | RAGE_HUMAN antibody | Receptor for advanced glycation end products antibody | Receptor for advanced glycosylation end products antibody | advanced glycosylation end product-sp
Specifications & Purity Recombinant, ExactAb™, Validated, See COA
Host species Rabbit
Specificity RAGE
Immunogen A synthetic peptide derived from human RAGE (AA 344-404).
Positive Control WB: Mouse lung and Rat lung lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human RAGE Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/2000
Protein Function：
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purifie
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage WB: Mouse lung lysates.

Associated Targets(Human)

AGER Tchem Advanced glycosylation end product-specific receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant RAGE Antibody (Ab124452) - Western Blot
All lanes: Recombinant RAGE Antibody (Ab124452) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 43 kDa
Observed band size: 48 kDa
Exposure time: 25.9 s


Application

Application Dilution info
WB

1/500-1/2000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0708447 Certificate of Analysis Jul 17, 2024 Ab124452
ZJ24F0708446 Certificate of Analysis Jul 17, 2024 Ab124452

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