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Recombinant PKN1 Antibody - Primary antibody, specific to PKN1, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab122157
Grouped product items
SKU Size
Availability
 Price Qty
Ab122157-10μl
10μl
2
$86.90
Ab122157-50μl
50μl
1
$249.90
Ab122157-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
Ab122157-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human PKN1 Antibody; WB; Unconjugated

View related series
Click to view target information: PKN1
Accession#:Q16512 (1) Gene ID:5585 (1) PAK1 (2) PKN1 (1) PRK1 (1)

Basic Description

Product Name Recombinant PKN1 Antibody - Primary antibody, specific to PKN1, Rabbit IgG
Synonyms DBK antibody | PAK 1 antibody | PAK-1 antibody | PAK1 antibody | PKC1 antibody | PKN ALPHA antibody | PKN antibody | Pkn1 antibody | PKN1_HUMAN antibody | PRK1 antibody | PRKCL1 antibody | Protease activated kinase 1 antibody | Protease-activated kinase 1
Specifications & Purity ExactAb™, Validated, Recombinant, 0.2 mg/mL
Host species Rabbit
Specificity PKN1
Immunogen A synthetic peptide derived from human PKN (AA 900-913).
Positive Control WB: Ramos, LNCaP, NIH/3T3 and C6 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human PKN1 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/1000
Protein Function
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 0.2 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PKN1 Tchem Serine/threonine-protein kinase N1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PKN1 Tchem Protein kinase N1 (787 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant PKN1 Antibody (Ab122157) - Western Blot
All lanes: Recombinant PKN1 Antibody (Ab122157) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 104 kDa
Observed band size: 117 kDa
Exposure time: 60.0 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607380 Certificate of Analysis Jun 26, 2024 Ab122157
ZJ24F0202725 Certificate of Analysis Feb 05, 2024 Ab122157
ZJ24F0202726 Certificate of Analysis Feb 05, 2024 Ab122157

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