Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab118565-10μl
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10μl |
2
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$66.90
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Ab118565-50μl
|
50μl |
1
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$189.90
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Ab118565-100μl
|
100μl |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$299.90
|
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Ab118565-1ml
|
1ml |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,699.90
|
|
Recombinant; Rabbit anti Human Noxa Antibody; WB; Unconjugated
| Product Name | Recombinant Noxa Antibody - Primary antibody, specific to PMAIP1, Rabbit IgG |
|---|---|
| Synonyms | Adult T cell leukemia derived PMA responsive antibody | APR antibody | APR_HUMAN antibody | ATL-derived antibody | Immediate early response protein APR antibody | Immediate-early-response protein APR antibody | NOXA antibody | Phorbol 12 myristate 13 acet |
| Specifications & Purity | Recombinant, ExactAb™, Validated, High Performance, See COA |
| Biochemical and Physiological Mechanisms | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1 |
| Host species | Rabbit |
| Specificity | PMAIP1 |
| Immunogen | A synthetic peptide derived from human Noxa (AA 31-44). |
| Positive Control | WB: HeLa, A549, HEK293, Jurkat, K562, NIH/3T3 and C6 cell lysates. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, High Performance, Recombinant, Validated |
| Product Description |
Rabbit anti Human Noxa Antibody, Recombinant, could be used for WB and so on. |
| Isotype | Rabbit IgG |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Recombinant Noxa Antibody (Ab118565) - Western Blot
All lanes: Recombinant Noxa Antibody (Ab118565) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 6 kDa
Observed band size: 14 kDa
NOXA can form a complex of approximately 32 kDa with pHSP27. The cross-linking of Noxa and p-HSP27 is essential for blocking NF-kB activation.(PMID:29363670)
Exposure time: 25.9 s
| Application | Dilution info |
|---|---|
| WB | 1/1000 - 1/5000 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 19, 2024 | Ab118565 | |
| Certificate of Analysis | Jun 19, 2024 | Ab118565 |