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Recombinant MK-3 Antibody - Primary antibody, specific to MAPKAPK3, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab115494
Grouped product items
SKU Size
Availability
 Price Qty
Ab115494-10μl
10μl
1
$69.90
Ab115494-50μl
50μl
1
$209.90
Ab115494-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab115494-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human MK-3 Antibody; WB; Unconjugated

View related series
Click to view target information: MAPKAPK3
3PK (1) Accession#:Q16644 (2) Gene ID:7867 (2) MAPKAPK3 (2) MK3 (1)

Basic Description

Product Name Recombinant MK-3 Antibody - Primary antibody, specific to MAPKAPK3, Rabbit IgG
Synonyms anti MAPKAPK3 antibody | Chromosome 3p kinase antibody | EC 2.7.11.1 antibody | MAP kinase-activated protein kinase 3 antibody | MAPK activated protein kinase 3 antibody | MAPK-activated protein kinase 3 antibody | MAPK3_HUMAN antibody | MAPKAP antibody |
Specifications & Purity Recombinant, ExactAb™, Validated, See COA
Host species Rabbit
Specificity MAPKAPK3
Immunogen A synthetic peptide derived from human MK3 (AA 12-58).
Positive Control WB: THP-1 and Jurkat cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human MK-3 Antibody, Recombinant, could be used for WB and so on.
Application:
· WB: 1/500-1/2000
Protein Function
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAPKAPK3 Tchem MAP kinase-activated protein kinase 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant MK-3 Antibody (Ab115494) - Western Blot
All lanes: Recombinant MK-3 Antibody (Ab115494) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 43 kDa
Observed band size: 39 kDa
Exposure time: 6.3 s

Recombinant MK-3 Antibody (Ab115494) - IP
Immunoprecipitate (IP) analysis using Recombinant MK-3 Antibody (Ab115494) at 1/50 dilution. (WB with Recombinant MK-3 Antibody (Ab115494)  at 1/1000 dilution)

Application

Application Dilution info
WB

1/500-1/2000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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