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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab111197-10μl
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10μl |
2
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$69.90
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Ab111197-50μl
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50μl |
1
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$199.90
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Ab111197-100μl
|
100μl |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$299.90
|
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Ab111197-1ml
|
1ml |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,699.90
|
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Recombinant; Rabbit anti Human IRF2 Antibody; WB; Unconjugated
| Product Name | Recombinant IRF2 Antibody - Primary antibody, specific to IRF2, Rabbit IgG | |
|---|---|---|
| Synonyms | DKFZp686F0244 antibody | Interferon regulatory factor 2 antibody | IRF 2 antibody | IRF-2 antibody | IRF2 antibody | IRF2_HUMAN antibody | DKFZp686F0244 | interferon regulatory factor 2 | IRF2 | IRF-2 | |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 1.0 mg/mL | |
| Host species | Rabbit | |
| Specificity | IRF2 | |
| Immunogen | A synthetic peptide derived from human IRF2 (AA 300-349) | |
| Positive Control | WB: HeLa, Jurkat, A549, MCF7, HT-29 and NIH/3T3 cell lysates. | |
| Conjugation | Unconjugated | |
| Grade | ExactAb™, Recombinant, Validated | |
| Product Description |
Rabbit anti Human IRF2 Antibody, Recombinant, could be used for WB and so on. Application:
Protein Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Post-translational Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity. The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter. |
| Isotype | Rabbit IgG |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | 1.0 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Recombinant IRF2 Antibody (Ab111197) - Western Blot
All lanes: Recombinant IRF2 Antibody (Ab111197) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 39 kDa
Observed band size: 45, 47 kDa
Exposure time: 120.0 s
| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 27, 2024 | Ab111197 | |
| Certificate of Analysis | Jun 27, 2024 | Ab111197 |