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Recombinant IRF2 Antibody - Primary antibody, specific to IRF2, Rabbit IgG

    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab111197
Grouped product items
SKU Size
Availability
Price Qty
Ab111197-10μl
10μl
2
$69.90
Ab111197-50μl
50μl
1
$199.90
Ab111197-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab111197-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

Recombinant; Rabbit anti Human IRF2 Antibody; WB; Unconjugated

Basic Description

Product Name Recombinant IRF2 Antibody - Primary antibody, specific to IRF2, Rabbit IgG
Synonyms DKFZp686F0244 antibody | Interferon regulatory factor 2 antibody | IRF 2 antibody | IRF-2 antibody | IRF2 antibody | IRF2_HUMAN antibody | DKFZp686F0244 | interferon regulatory factor 2 | IRF2 | IRF-2
Specifications & Purity ExactAb™, Validated, Recombinant, 1.0 mg/mL
Host species Rabbit
Specificity IRF2
Immunogen A synthetic peptide derived from human IRF2 (AA 300-349)
Positive Control WB: HeLa, Jurkat, A549, MCF7, HT-29 and NIH/3T3 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human IRF2 Antibody, Recombinant, could be used for WB and so on.

Application:

WB: 1/500-1/1000

Protein Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Post-translational

Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity. The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

IRF2 Tbio Interferon regulatory factor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant IRF2 Antibody (Ab111197) - Western Blot
All lanes: Recombinant IRF2 Antibody (Ab111197) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 39 kDa
Observed band size: 45, 47 kDa
Exposure time: 120.0 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0607521 Certificate of Analysis Jun 27, 2024 Ab111197
ZJ24F0607520 Certificate of Analysis Jun 27, 2024 Ab111197

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