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Rac1/2/3 Antibody - Primary antibody, specific to RAC1/RAC2/RAC3, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab124312
Grouped product items
SKU Size
Availability
 Price Qty
Ab124312-10μl
10μl
5
$66.90
Ab124312-50μl
50μl
2
$199.90
Ab124312-100μl
100μl
1
$279.90
Ab124312-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

pAb; Rabbit anti Human Rac1/2/3 Antibody; WB; Unconjugated

View related series
Click to view target information: RAC1 Click to view target information: RAC2 Click to view target information: RAC3
Accession#:P15153 (1) Accession#:P60763 (2) Accession#:P63000 (1) Gene ID:5879 (1) Gene ID:5880 (1) Gene ID:5881 (2) RAC1 (1) Rac1/2/3 (1) RAC2 (1) RAC3 (2)

Basic Description

Product Name Rac1/2/3 Antibody - Primary antibody, specific to RAC1/RAC2/RAC3, Rabbit IgG
Synonyms Cell migration-inducing gene 5 protein antibody | EN-7 antibody | GX antibody | HSPC022 antibody | MIG5 antibody | p21-Rac1 antibody | p21-Rac2 antibody | p21-Rac3 antibody | RAC1 antibody | RAC2 antibody | RAC3 antibody | Ras-like protein TC25 antibody |
Specifications & Purity ExactAb™, Validated, 1.2 mg/mL
Host species Rabbit
Specificity RAC1/RAC2/RAC3
Immunogen A synthetic peptide derived from human Rac1/2/3 (AA 1-120）.
Positive Control WB: HeLa, NIH/3T3, HEK293, Jurkat, A431, HT-29 and C6 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Rabbit anti Human Rac1/2/3 Antibody, Polyclonal, could be used for WB and so on.
Application:
WB: 1/500-1/1000
Protein Function
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 1.2 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

RAC1 Tbio Ras-related C3 botulinum toxin substrate 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
RAC2 Tbio Ras-related C3 botulinum toxin substrate 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
RAC3 Tbio Ras-related C3 botulinum toxin substrate 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
RAC2 Tbio Ras-related C3 botulinum toxin substrate 2 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAC3 Tbio Ras-related C3 botulinum toxin substrate 3 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAC1 Tbio Ras-related C3 botulinum toxin substrate 1 (221 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Rac1/2/3 Antibody (Ab124312) - Western Blot
All lanes: Rac1/2/3 Antibody (Ab124312) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 21 kDa
Observed band size: 22 kDa
Exposure time: 19.2 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F0901109 Certificate of Analysis Sep 24, 2023 Ab124312
ZJ23F0901108 Certificate of Analysis Sep 24, 2023 Ab124312

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