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PML Protein Antibody - Primary antibody, specific to PML Protein, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab122429
Grouped product items
SKU Size
Availability
 Price Qty
Ab122429-10μl
10μl
10
$69.90
Ab122429-50μl
50μl
4
$199.90
Ab122429-100μl
100μl
2
$309.90
Ab122429-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,899.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

pAb; Rabbit anti Human PML Protein Antibody; WB; Unconjugated

View related series
Click to view target information: PML
Accession#:P29590 (2) Gene ID:5371 (2) MYL (1) PML (2)

Basic Description

Product Name PML Protein Antibody - Primary antibody, specific to PML Protein, Rabbit IgG
Synonyms MYL | PP8675 | RNF71 | TRIM19 | Acure promyelocytic leukemia, inducer of antibody | MYL antibody | Pml antibody | PML_HUMAN antibody | PP8675 antibody | Probable transcription factor PML antibody | Promyelocytic leukemia antibody | Promyelocytic leukemia
Specifications & Purity Carrier Free, ExactAb™, Validated, High Performance, See COA
Host species Rabbit
Specificity PML Protein
Immunogen Recombinant PML expressed in E.coli (AA 59-239).
Positive Control WB: HEK293, K562, A549, NIH/3T3 and C6 cell lysates.
Conjugation Unconjugated
Grade Carrier Free, ExactAb™, High Performance, Validated
Product Description

Rabbit anti Human PML Protein Antibody, Polyclonal, could be used for WB and so on.
Application
WB: 0.01-2 µg/mL
Protein Function
Key component of PML nuclear bodies that regulate a large number of cellular processes by facilitating post-translational modification of target proteins, promoting protein-protein contacts, or by sequestering proteins. Functions as tumor suppressor. Required for normal, caspase-dependent apoptosis in response to DNA damage, FAS, TNF, or interferons. Plays a role in transcription regulation, DNA damage response, DNA repair and chromatin organization. Plays a role in processes regulated by retinoic acid, regulation of cell division, terminal differentiation of myeloid precursor cells and differentiation of neural progenitor cells. Required for normal immunity to microbial infections. Plays a role in antiviral response. In the cytoplasm, plays a role in TGFB1-dependent processes. Regulates p53/TP53 levels by inhibiting its ubiquitination and proteasomal degradation. Regulates activation of p53/TP53 via phosphorylation at 'Ser-20'. Sequesters MDM2 in the nucleolus after DNA damage, and thereby inhibits ubiquitination and degradation of p53/TP53. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates RB1 phosphorylation and activity. Required for normal development of the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies, and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcription activity of ELF4. Inhibits specifically the activity of the tetrameric form of PKM2. Together with SATB1, involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Regulates PTEN compartmentalization through the inhibition of USP7-mediated deubiquitinylation.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Antigen affinity purified + Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PML Tbio Protein PML (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

PML Protein Antibody (Ab122429) - Western Blot
All lanes: PML Protein Antibody (Ab122429) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 98 kDa
Observed band size: 48, 85, 98 kDa
PML has12 isoforms. A large number of alternative spliced transcripts are synthesized from the PML gene, resulting in a variety of PML proteins ranging in molecular weight from 48 - 98 kDa (PMID:11704850).
Exposure time: 60.0 s

PML Protein Antibody (Ab122429) - Western Blot
All lanes: PML Protein Antibody (Ab122429) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 98 kDa
Observed band size: 98 kDa
Exposure time: 10.0 s


Application

Application Dilution info
WB

0.01-2 µg/mL

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0606838 Certificate of Analysis Jun 13, 2024 Ab122429
ZJ24F0606839 Certificate of Analysis Jun 13, 2024 Ab122429
ZJ24F0606840 Certificate of Analysis Jun 13, 2024 Ab122429

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