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Nivolumab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PDCD1/PD-1/CD279, >95%, high purity, Human IgG4SP, Antibody of programmed cell death 1 (CD279), Antibody of programmed cell death 1 (CD279)

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
N411994
Grouped product items
SKU Size
Availability
 Price Qty
N411994-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$159.90
N411994-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$664.90
N411994-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,196.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG4SP; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: PDCD1
Accession#:Q15116 (38) CD279 (28) Gene ID:5133 (38) PD1 (37) PDCD1 (39)

Basic Description

Product Name Nivolumab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PDCD1/PD-1/CD279, >95%, high purity, Human IgG4SP, Antibody of programmed cell death 1 (CD279)
Synonyms CID 167682467 | hPD-1 | Protein PD-1
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Possible cell death inducer, in association with other factors.
Host species Human
Specificity PDCD1/PD-1/CD279
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of programmed cell death 1 (CD279)
Product Description

Nivolumab (anti-PD-1) is a programmed death receptor-1 (PD-1) blocking human IgG4SP antibody to treat advanced (metastatic) non-small cell lung cancer.

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.4 kDa (Light Chain) & 53.3 kDa (Heavy Chain), under reducing conditions; 178.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 946414-94-4

Associated Targets(Human)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Nivolumab (anti-PD-1) (N411994) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling PD-1 (red) with Nivolumab (anti-PD-1) (N411994). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Nivolumab (anti-PD-1) (N411994) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling PD-1 (red) with Nivolumab (anti-PD-1) (N411994) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Nivolumab (anti-PD-1) (N411994) - ELISA
Immobilized Recombinant Human PD-1 protein (rp176241) at 1.0 μg/mL can bind Nivolumab (anti-PD-1) (N411994) with the EC₅₀ of 27.77 ng/mL.

Nivolumab (anti-PD-1) (N411994) - ELISA
Immobilized Recombinant hu-PD -1-His protein at 2.0 μg/mL can bind Nivolumab (anti-PD-1) (N411994) with the EC₅₀ of 1.204 ng/mL.

Nivolumab (anti-PD-1) (N411994) - SEC
The purity of Nivolumab (anti-PD-1) (N411994) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
ZJ25F0420406 Certificate of Analysis Apr 14, 2025 N411994
ZJ23F0800920 Certificate of Analysis Aug 26, 2023 N411994
ZJ23F0800919 Certificate of Analysis Aug 26, 2023 N411994
ZJ23F0800918 Certificate of Analysis Aug 26, 2023 N411994

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