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Toripalimab (anti-PD-1) - Primary antibody, specific to PDCD1, Human IgG1, ANTAGONIST of Programmed cell death protein 1 antagonist, ANTAGONIST of Programmed cell death protein 1 antagonist

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182801
Grouped product items
SKU Size
Availability
 Price Qty
Ab182801-100μg
100μg
10
$19.90
Ab182801-1mg
1mg
4
$99.90
Ab182801-5mg
5mg
1
$239.90
Ab182801-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$389.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: PDCD1
Accession#:Q15116 (38) CD279 (28) Gene ID:5133 (38) PD-1 (9)

Basic Description

Product Name Toripalimab (anti-PD-1) - Primary antibody, specific to PDCD1, Human IgG1, ANTAGONIST of Programmed cell death protein 1 antagonist
Synonyms CD279 antibody | CD279 antigen antibody | hPD 1 antibody | hPD l antibody | hPD-1 antibody | hSLE1 antibody | PD 1 antibody | PD-1 antibody | PD1 antibody | PDCD 1 antibody | PDCD1_HUMAN antibody | PDCD1 antibody | Programmed cell death 1 antibody | Progr
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity PDCD1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action ANTAGONIST of Programmed cell death protein 1 antagonist
Product Description

Toripalimab (anti-PD-1) is the first domestic anti-tumor PD-1 antibody in China. Toripalimab (anti-PD-1) is a selective, recombinant, humanized monoclonal antibody against PD-1. Toripalimab (anti-PD-1) is able to bind to PD-1 and block the interaction with its ligands. Toripalimab (anti-PD-1) has exhibited primary anti-tumor effects in tumors such as melanoma, lung cancer, digestive tract tumors, hepatobiliary and pancreatic tumors, neuroendocrine neoplasms, nasopharyngeal carcinoma and urothelial carcinoma.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.1 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 212.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1924598-82-2

Associated Targets(Human)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Toripalimab (anti-PD-1) (Ab182801) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells (24h) labelling PD-1 (red) with Toripalimab (anti-PD-1) (Ab182801) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Toripalimab (anti-PD-1) (Ab182801) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) MOLT-4 cells (24h) labelling PD-1 (red) with Toripalimab (anti-PD-1) (Ab182801) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Toripalimab (anti-PD-1) (Ab182801) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 1.0 μg/mL can bind Toripalimab (anti-PD-1) (Ab182801) with the EC50 of 14.20 ng/mL.​

Toripalimab (anti-PD-1) (Ab182801) - SEC
The purity of Toripalimab (anti-PD-1) (Ab182801) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0505642 Certificate of Analysis May 15, 2024 Ab182801
ZJ24F0505641 Certificate of Analysis May 15, 2024 Ab182801
ZJ24F0505640 Certificate of Analysis May 15, 2024 Ab182801

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