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BRCA1 Antibody - Primary antibody, specific to BRCA1, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab091635
Grouped product items
SKU Size
Availability
 Price Qty
Ab091635-10μl
10μl
2
$66.90
Ab091635-50μl
50μl
1
$199.90
Ab091635-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab091635-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

pAb; Rabbit anti Human BRCA1 Antibody; WB; Unconjugated

View related series
Click to view target information: BRCA1
Accession#:P38398 (2) BRCA1 (2) Gene ID:672 (2)

Basic Description

Product Name BRCA1 Antibody - Primary antibody, specific to BRCA1, Rabbit IgG
Synonyms BRCA 1 antibody | BRCA1 antibody | BRCA1 DNA repair associated antibody | BRCA1/BRCA2 containing complex subunit 1 antibody | BRCA1/BRCA2-containing complex, subunit 1 antibody | BRCA1_HUMAN antibody | BRCAI antibody | BRCC 1 antibody | BRCC1 antibody | B
Specifications & Purity ExactAb™, Validated, 1.0 mg/mL
Host species Rabbit
Specificity BRCA1
Immunogen A synthetic peptide derived from human BRCA1 (AA 1391-1440)
Positive Control WB: C6, NIH/3T3, A549, HEK293 and HeLa cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Rabbit anti Human BRCA1 Antibody, Polyclonal, could be used for WB and so on.

Application

  • WB: 1/500-1/1000

Protein Function

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.

Product Properties

Isotype Rabbit IgG
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

BRCA1 Tchem Breast cancer type 1 susceptibility protein (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

BRCA1 Antibody (Ab091635) - Western Blot
All lanes: BRCA1 Antibody (Ab091635) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 208 kDa
Observed band size: 191 kDa
Exposure time: 48.8 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0102423 Certificate of Analysis Jan 15, 2024 Ab091635
ZJ24F0102424 Certificate of Analysis Jan 15, 2024 Ab091635

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