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代谢疾病靶点
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Recombinant Human TNF-alpha Protein种属: 人(Human) Accession #: P01375表达系统: E. coli 蛋白标签: No tag 内毒素水平: <0.1 EU/μg生物活性: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.05 ng/mL.
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Recombinant Human IL-2 Protein种属: 人(Human) Accession #: P60568表达系统: CHO-K1 蛋白标签: His 内毒素水平: <1.0 EU/μg生物活性: 1、Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is typically less than 2.5 ng/mL. 2、Measured in a cell proliferation assay using mouse splenocytes. The ED50 for this effect is typically less than 30.0 ng/mL.
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Recombinant Human Osteoprotegerin Protein种属: 人(Human) Accession #: O00300表达系统: E. coli 蛋白标签: No tag 内毒素水平: <1.0 EU/μg生物活性: Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
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Recombinant Human Leptin Protein种属: 人(Human) Accession #: P41159表达系统: E. coli 蛋白标签: No tag 内毒素水平: <1.0 EU/μg生物活性: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
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Recombinant Human IL-2 Receptor Alpha Protein种属: 人(Human) Accession #: P01589表达系统: HEK293 蛋白标签: C-His 内毒素水平: <1.0 EU/μg生物活性: 1. Measured by its ability to inhibit the IL-2-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 0.2 ‑1.2 µg/mL in the presence of 30 ng/mL of recombinant human IL-2. 2. Immobilized Recombinant Human IL-2 Protein (rp156004) at 1 μg/mL can bind biotinylated Recombinant Human IL-2 Receptor Alpha Protein (rp147480).
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Recombinant Human IL-6R Protein种属: 人(Human) Accession #: P08887表达系统: HEK293 蛋白标签: C-His 内毒素水平: <1.0 EU/μg生物活性: 1. Immobilized Recombinant Human IL-6 Protein at 2 μg/mL can bind Recombinant Human IL-6R Protein (rp147628) the EC50 is 8.0 - 24.0 ng/mL. 2. Measured by its ability to enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 10.0 - 60.0 ng/mL.3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human IL-6R Protein (rp147628) bound Anti-IL6R Antibody was 0.1 nM.
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Recombinant Human HVEM/TNFRSF14 Protein种属: 人(Human) Accession #: Q92956表达系统: 毕赤酵母 蛋白标签: C-hFc 内毒素水平: <0.1 EU/μg生物活性: Fully biologically active when compared to standard. The biologically active as determined by its ability to inhibit TNF-beta -mediated cytotoxicity using murine L929 cells.
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Recombinant Human IL-10 Protein种属: 人(Human) Accession #: P22301表达系统: E. coli 蛋白标签: No tag 内毒素水平: <1.0 EU/μg生物活性: 1. Measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED₅₀ for this effect is typically 1.0 - 8.0 ng/mL. 2. Immobilized Recombinant Human IL-10 Protein (rp147355) at 2 μg/mL can bind Recombinant Rhesus IL10RA Protein (Fc Tag) the EC₅₀ for this effect is 100.0 - 300.0 ng/mL.
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Recombinant Human NRG1/HRG1 Protein种属: 人(Human) Accession #: Q02297表达系统: HEK293 蛋白标签: C-His 内毒素水平: <0.1 EU/μg生物活性: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 20‑100 ng/mL.
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Recombinant Human FGF19 Protein种属: 人(Human) Accession #: O95750表达系统: E. coli 蛋白标签: N-His 内毒素水平: <1.0 EU/μg生物活性: FGF19 is a member of the fibroblast growth factor (FGF) family. FGFs are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. In general, FGFs are expressed during embryonic development and in restricted adult tissues. Human FGF-19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites. FGF19-FGFR1 is one of paired transcripts mediating the dialogues between extraembryonic membrane and endometrium. A functional binding ELISA assay was conducted to detect the interaction of Recombinant Human FGF19 Protein (rp145934) and recombinant human FGFR1, the EC50 for this effect is 0.16 μg/mL.
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Recombinant Human FGFR4 protein种属: 人(Human) Accession #: P22455表达系统: HEK293 蛋白标签: C-hFc & His 内毒素水平: <0.1 EU/μg生物活性: Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.03-0.12 ng/mL.
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Recombinant Human IL-1 beta Protein种属: 人(Human) Accession #: P01584表达系统: E. coli 蛋白标签: C-His 内毒素水平: <1.0 EU/μg生物活性: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.217-0.870 ng/mL.
