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Recombinant Human HVEM/TNFRSF14 Protein

Recombinant Human HVEM/TNFRSF14 Protein

级别和纯度:

≥95%(SDS-PAGE&HPLC)

表达系统: 毕赤酵母
Accession #: Q92956
蛋白标签: C-hFc
生物活性: Fully biologically active when compared to standard. The biologically active as determined by its ability to inhibit TNF-beta -mediated cytotoxicity using murine L929 cells.
内毒素水平: <0.1 EU/μg

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货号 (SKU)	包装规格	是否现货
rp152533-10μg	10μg	现货
rp152533-50μg	50μg	现货
rp152533-100μg	100μg	现货
rp152533-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: TNFRSF14

Accession#:Q92956 (3) Gene ID:8764 (3) HVEM (3) TNFRSF14 (3)

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基本描述

产品名称	Recombinant Human HVEM/TNFRSF14 Protein
别名	重组人HVEM蛋白 \| 重组人TNFRSF14蛋白 \| 重组人肿瘤坏死因子受体超家族成员14蛋白 \| 重组人 HVEM/TNFRSF14 蛋白
英文别名	ATAR \| CD270 antigen \| CD270 \| CD40-like protein \| Herpes virus entry mediator A \| Herpesvirus entry mediator A \| HveA \| HVEM \| HVEMTR2HVEAATAR \| LIGHTR \| TNFRSF14 \| tumor necrosis factor receptor superfamily member 14 \| tumor necrosis factor receptor sup
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE&HPLC)
产品介绍	Purity Function >95% (SDS-PAGE&HPLC) Endotoxin level <0.1 EU/μg Function Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
生物活性	Fully biologically active when compared to standard. The biologically active as determined by its ability to inhibit TNF-beta -mediated cytotoxicity using murine L929 cells.
内毒素水平	<0.1 EU/μg
表达系统	毕赤酵母
种属	人(Human)
氨基酸	39-202 aa
序列	LPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVEPKSSDKTHTCPPCPAPEFEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPTPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
纯度	>95% (SDS-PAGE&HPLC)
蛋白标签	C-hFc
无载体	Yes
无动物源	Yes
Accession #	Q92956
来源	重组表达
预测分子量	58 kDa
SDS-PAGE	70 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from a 0.2 µm filtered concentrated solution in 1*PBS, pH7.4, with 3 % Trehalose.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	自收到之日起 12 个月，-20 至 -70 °C。1 个月，复溶后无菌条件下 2 至 8 °C。3 个月，复溶后在无菌条件下 -20 至 -70 °C。收货后建议分装。避免冻融循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human HVEM/TNFRSF14 Protein (rp152533)

Recombinant Human HVEM/TNFRSF14 Protein (rp152533) - SDS-PAGE
Recombinant Human HVEM/TNFRSF14 Protein was resolved with SDS-PAGE under reducing (N) and visualized by Coomassie® Blue staining. Showing a band at 70.0 kDa.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101649	分析证书	rp152533
ZJ23F1101650	分析证书	rp152533
ZJ23F1101651	分析证书	rp152533

引用文献

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C et al.. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res, 13 (10): (2265-70). [PMID:12975309]
2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039]
3. Montgomery, R I RI, Warner, M S MS, Lum, B J BJ and Spear, P G PG.. (1996) Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family.. Cell, (1): [PMID:8898196]
4. Hsu, H H and 5 more authors.. (1997) ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.. The Journal of biological chemistry, (23): [PMID:9153189]
5. Marsters, S A SA and 5 more authors.. (1997) Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.. The Journal of biological chemistry, (30): [PMID:9162022]
6. Kwon, B S BS and 15 more authors.. (1997) A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation.. The Journal of biological chemistry, (30): [PMID:9162061]
7. Mauri, D N DN and 11 more authors.. (1998) LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.. Immunity, [PMID:9462508]
8. Krummenacher, C C and 9 more authors.. (1998) Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.. Journal of virology, [PMID:9696799]
9. Tamada, K K and 9 more authors.. (2000) LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10754304]
10. Carfí, A A and 6 more authors.. (2001) Herpes simplex virus glycoprotein D bound to the human receptor HveA.. Molecular cell, [PMID:11511370]
11. Struyf, Frank F and 5 more authors.. (2002) Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals.. The Journal of infectious diseases, (1): [PMID:11756979]
12. Zhang, Zemin Z and Henzel, William J WJ.. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein science : a publication of the Protein Society, [PMID:15340161]
13. Compaan, Deanne M DM and 5 more authors.. (2005) Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.. The Journal of biological chemistry, (25): [PMID:16169851]
14. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414]
15. Cai, Guifang G and 5 more authors.. (2008) CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.. Nature immunology, [PMID:18193050]
16. Cheung, Timothy C TC and 12 more authors.. (2009) T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:19915044]
17. Šedý, John R JR and 8 more authors.. (2013) CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:23761635]
18. Bian, Yangyang Y and 9 more authors.. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.. Journal of proteomics, (16): [PMID:24275569]

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