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Recombinant Human NRG1/HRG1 Protein

  • 表达系统: HEK293
  • Accession #: Q02297
  • 蛋白标签: C-His
  • 生物活性: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 20‑100 ng/mL.
  • 内毒素水平: <0.1 EU/μg
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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp149423-10μg
10μg 现货 Stock Image
rp149423-50μg
50μg 现货 Stock Image
rp149423-100μg
100μg 现货 Stock Image
rp149423-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human NRG1/HRG1 Protein
别名 重组人 NRG1 蛋白 | 重组人类 NRG1/HRG1 蛋白
英文别名 Acetylcholine receptor-inducing activity | Acetylcholine receptor-inducing activity, CHICK, homolog of | ARIA | Breast cancer cell differentiation factor p45 | GGF | GGF2 | Glial growth factor | Heregulin | heregulin, alpha (45kD, ERBB2 p185-activator) |
规格或纯度 ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
产品介绍


Purity
≥95% (SDS-PAGE)
Endotoxin level
<0.1 EU/ug
Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

生物活性 Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 20‑100 ng/mL.
内毒素水平 <0.1 EU/μg
表达系统 HEK293
种属 人(Human)
氨基酸 20-241 aa
序列 SGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKHHHHHH
纯度 >92%(SDS-PAGE)
蛋白标签 C-His
无载体 Yes
无动物源 Yes
Accession # Q02297
来源 重组表达
预测分子量 24.8 kDa
SDS-PAGE 40-43 kDa, under reducing conditions

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶 Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型 蛋白质

图片

Recombinant Human NRG1/HRG1 Protein (rp149423) - Protein Bioactivity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 77.6 ng/mL.

Recombinant Human NRG1/HRG1 Protein (rp149423) - SDS-PAGE
3 μg/lane of Recombinant Human NRG1/HRG1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 40 - 50 kDa.

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批号(Lot Number) 证书类型 货号
ZJ24F1215018 分析证书 rp149423
ZJ24F1215016 分析证书 rp149423
ZJ24F1215017 分析证书 rp149423
ZJ24F0910294 分析证书 rp149423
ZJ24F0910295 分析证书 rp149423
ZJ24F0910296 分析证书 rp149423

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