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Recombinant GCG Antibody

    应用:
  • IHC
  • 宿主种属: 兔(Rabbit)
  • 种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse)
  • 亚型: Rabbit IgG
  • 克隆号: EP3070
  • 偶联: Unconjugated
有货

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab105544-10μl
10μl 现货 Stock Image
Ab105544-50μl
50μL 现货 Stock Image
Ab105544-100μl
100μL 现货 Stock Image
Ab105544-1ml
1ml 期货 Stock Image

基本信息

产品名称 Recombinant GCG Antibody
别名 重组抗胰高血糖素抗体 | 重组Anti-Glucagon抗体 | Glucagon重组抗体 | Anti-Glucagon抗体 | Glucagon抗体 | GCG抗体 | 重组GCG抗体
英文别名 GCG antibody
规格或纯度 ExactAb™, Validated, Recombinant, 0.3 mg/mL
宿主种属 兔(Rabbit)
特异性 Human
种属反应性 人(Human),大鼠(Rat),小鼠(Mouse)
免疫原 Synthetic peptide within Human Glucagon aa 50-150 (N terminal). The exact sequence is proprietary.
阳性对照 IHC: Human pancreas tissue
偶联 Unconjugated

产品属性

克隆类型 重组抗体
克隆号 EP3070
Format Whole IgG
亚型 IgG
轻链亚型 kappa
SDS-PAGE 150 kDa
纯化方法 Protein A purified
物理外观 Liquid
储存缓冲液 pH: 7.20 Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA
防腐剂 0.01% Sodium azide
浓度 0.3 mg/mL
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 4°C 下运输。在 +4°C 下短期储存(1-2 周)。收货后建议分装。长期储存于 -20°C。避免冷冻/解冻循环。
分子类型 抗体

关联靶点(人)

GATA4 Tbio 转录因子 GATA-4(Transcription factor GATA-4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GCG Tchem 胰高血糖素(Glucagon) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GCG Tchem Glucagon (136 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Recombinant Glucagon Antibody (Ab105544) - IHC
Immunohistochemistry analysis of paraffin-embedded human pancreas tissue using Recombinant Glucagon Antibody (Ab105544). Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.

应用

应用名称 稀释比例
IHC

1/100 - 1/200

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F1011927 分析证书 Ab105544
ZJ23F0700718 分析证书 Ab105544
ZJ23F0700717 分析证书 Ab105544

引用文献

1. Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC.  (1983)  Exon duplication and divergence in the human preproglucagon gene..  Nature,  304  (5924): (368-71).  [PMID:6877358]
2. Rouillé Y, Bianchi M, Irminger JC, Halban PA.  (1997)  Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon..  FEBS Lett,  413  (1): (119-23).  [PMID:9287128]
3. Bonic A, Mackin RB.  (2003)  Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment..  Protein Expr Purif,  28  (1): (15-24).  [PMID:12651102]
4. Kim RM, Chang J, Lins AR, Brady E, Candelore MR, Dallas-Yang Q, Ding V, Dragovic J, Iliff S, Jiang G, Mock S, Qureshi S, Saperstein R, Szalkowski D, Tamvakopoulos C, Tota L, Wright M, Yang X, Tata JR, Chapman K, Zhang BB, Parmee ER..  (2008)  Discovery of potent, orally active benzimidazole glucagon receptor antagonists..  Bioorg Med Chem Lett,  18  (13): (3701-3705).  [PMID:18539028] [10.1016/j.bmcl.2008.05.072]
5. Orskov, C C, Bersani, M M, Johnsen, A H AH, Højrup, P P and Holst, J J JJ..  (1989)  Complete sequences of glucagon-like peptide-1 from human and pig small intestine..  The Journal of biological chemistry,  (5): [PMID:2753890]
6. Drucker, D J DJ and Asa, S S..  (1988)  Glucagon gene expression in vertebrate brain..  The Journal of biological chemistry,  (25): [PMID:2901414]
7. White, J W JW and Saunders, G F GF..  (1986)  Structure of the human glucagon gene..  Nucleic acids research,  (25): [PMID:3725587]
8. Orskov, C C, Wettergren, A A and Holst, J J JJ..  (1993)  Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable..  Diabetes,  [PMID:8482423]
9. Sturm, N S NS and 7 more authors..  (1998)  Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity..  Journal of medicinal chemistry,  (16): [PMID:9667960]
10. and Drucker DJ..  (1999)  Glucagon-like Peptide 2..  Trends in endocrinology and metabolism: TEM,  [PMID:10322410]
11. Kieffer, T J TJ and Habener, J F JF..  (1999)  The glucagon-like peptides..  Endocrine reviews,  [PMID:10605628]
12. Chang, Xiaoqing X, Keller, Danielle D, O'Donoghue, Seán I SI and Led, Jens J JJ..  (2002)  NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer..  FEBS letters,  (27): [PMID:11943215]
13. Thomsen, J J, Kristiansen, K K, Brunfeldt, K K and Sundby, F F..  (1972)  The amino acid sequence of human glucagon..  FEBS letters,  (1): [PMID:11946536]
14. and Drucker, Daniel J DJ..  (2003)  Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis..  Molecular endocrinology (Baltimore, Md.),  [PMID:12554744]
15. Jiang, Guoqiang G and Zhang, Bei B BB..  (2003)  Glucagon and regulation of glucose metabolism..  American journal of physiology. Endocrinology and metabolism,  [PMID:12626323]
16. Ying, Jinfa J, Ahn, Jung-Mo JM, Jacobsen, Neil E NE, Brown, Michael F MF and Hruby, Victor J VJ..  (2003)  NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles..  Biochemistry,  (18): [PMID:12627948]
17. Cohen, Mark A MA and 8 more authors..  (2003)  Oxyntomodulin suppresses appetite and reduces food intake in humans..  The Journal of clinical endocrinology and metabolism,  [PMID:14557443]
18. Tadokoro, R R and 5 more authors..  (2003)  Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants..  Acta paediatrica (Oslo, Norway : 1992),  [PMID:14632334]
19. Brubaker, Patricia L PL and Anini, Younes Y..  (2003)  Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2..  Canadian journal of physiology and pharmacology,  [PMID:14719035]
20. Hillier, Ladeana W LW and 121 more authors..  (2005)  Generation and annotation of the DNA sequences of human chromosomes 2 and 4..  Nature,  (7): [PMID:15815621]
21. Ellingsgaard, Helga H and 20 more authors..  (2011)  Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells..  Nature medicine,  (30): [PMID:22037645]

溶液计算器