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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab190129-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$109.90
|
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Ab190129-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$519.90
|
|
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Ab190129-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,299.90
|
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Ab190129-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,079.90
|
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | TRU-015 (anti-CD20) - Primary antibody, specific to MS4A1, Human IgG1 |
|---|---|
| Synonyms | APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | This protein may be involved in the regulation of B-cell activation and proliferation. |
| Host species | Human |
| Specificity | MS4A1 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
TRU-015 (anti-CD20) is a small proprietary antibody-based single-chain polypeptide that binds to CD20 and effectively depleted B cells. It exhibits anti-tumor activity in human tumor xenograft models. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
TRU-015 (anti-CD20) (Ab190129) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20 with TRU-015 (anti-CD20) (Ab190129) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
TRU-015 (anti-CD20) (Ab190129) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20 (red) with TRU-015 (anti-CD20) (Ab190129) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
TRU-015 (anti-CD20) (Ab190129) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20 (red) with TRU-015 (anti-CD20) (Ab190129) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
TRU-015 (anti-CD20) (Ab190129) - ELISA
Immobilized Recombinant Hu-CD20-VLP protein at 16.0 μg/mL can bind TRU-015 (anti-CD20) (Ab190129) with the EC50 of 2.32 ng/mL.
TRU-015 (anti-CD20) (Ab190129) - SEC
The purity of TRU-015 (anti-CD20) (Ab190129) is more than 95% verified by HPLC.
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