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Ocrelizumab (anti-CD20) - Primary antibody, specific to MS4A1, >95%, high purity, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1), Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1)

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175614
Grouped product items
SKU Size
Availability
 Price Qty
Ab175614-100μg
100μg
10
$59.90
Ab175614-1mg
1mg
4
$279.90
Ab175614-5mg
5mg
1
$739.90
Ab175614-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: MS4A1
Accession#:P11836 (34) CD20 (35) CD20 (membrane-spanning 4-domains，subfamily A，member 1) Antibody (3) Gene ID:931 (34) MS4A1 (35)

Basic Description

Product Name Ocrelizumab (anti-CD20) - Primary antibody, specific to MS4A1, >95%, high purity, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1)
Synonyms APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity MS4A1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1)
Product Description

Ocrelizumab (anti-CD20) is an anti-CD20 antibody that depletes circulating immature and mature B cells but spares CD20-negative plasma cells. The effector mechanisms of Ocrelizumab (anti-CD20) are complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity. Ocrelizumab (anti-CD20) is the first monoclonal antibody for secondary primary progressive multiple sclerosis (PPMS).

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.82 kDa
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 637334-45-3

Associated Targets(Human)

MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ocrelizumab (anti-CD20) (Ab175614) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20 (red) with Ocrelizumab (anti-CD20) (Ab175614). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Ocrelizumab (anti-CD20) (Ab175614) - SEC
The purity of Ocrelizumab (anti-CD20) (Ab175614) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0102656 Certificate of Analysis Jan 30, 2024 Ab175614
ZJ24F0102655 Certificate of Analysis Jan 30, 2024 Ab175614
ZJ24F0102654 Certificate of Analysis Jan 30, 2024 Ab175614

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